IL-3 R alpha

IL-3 R alpha

IL-3 R alpha Overview

Molecule Name
Interleukin-3 receptor subunit alpha
Synonyms
IL3R,IL3RA,IL-3Ra,IL-3R-alpha,IL3RAY,IL3RX,IL3RY,CD123 antigen,CD123,hIL3Ra,hIL-3Ra,MGC34174,IL-3 R alpha
Drug Development Progress
Drugs in Clinical Trials40
Approved Drugs1
Highest Development StageApproved
Target Synonym
IL3RY,IL-3RA,CD123 Antigen,IL3RX,IL-3R Subunit Alpha,IL3R,IL-3 Receptor Subunit Alpha,IL-3 Receptor Alpha SP2 Isoform,Interleukin 3 Receptor Subunit Alpha,IL3RAY,IL-3R-Alpha,CD123,HIL-3Ra,IL3RA,Interleukin 3 Receptor, Alpha (Low Affinity),Interleukin-3 Receptor Subunit Alpha,Interleukin-3 Receptor alpha Subunit
Background
Interleukin 3 receptor alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123) is a 70-kD glycoprotein member of the hematopoietin receptor superfamily. This protein associates with a beta subunit common to the receptors for IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) to form a high-affinity receptor for IL-3. The interleukin-3 receptor α chain (CD123) has been identified as a potential immunotherapeutic target because it is overexpressed in AML compared with normal hematopoietic stem cells.

IL-3 R alpha Product List

Species
  • Human(10)
  • Canine(1)
  • Cynomolgus(1)
  • Mouse(1)
Tag
  • His Tag(7)
  • Fc Tag(2)
  • Avi Tag(1)
  • Fc Tag & Avi Tag(1)
  • His Tag & Avi Tag(1)
  • Llama IgG Fc Tag(1)
Host
  • HEK293(13)
Conjugate
  • Unconjugated(6)
  • Biotin-labeled(3)
  • FITC Labeled(2)
  • APC Labeled(1)
  • PE Labeled(1)
Grade
  • RUO(12)
  • PG (pre-GMP)(1)
Low Endotoxin
  • Yes(2)
  • No(11)
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Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
TalacotuzumabCSL-362; JNJ-473; CSL-362-AML; JNJ-56022473; IL-13 MAb-CSLPhase 2 ClinicalCsl Ltd
Leukemia, Myeloid, Acute; Myelodysplastic Syndromes
Details
VibecotamabXmAb-14045Phase 2 ClinicalXencor Inc
Blastic Plasmacytoid Dendritic Cell Neoplasm; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Details
CD123 CAR-T cell therapy(Chongqing Precision Biotechnology)Phase 2 ClinicalChongqing Precision Biotechnology Co Ltd
Blastic Plasmacytoid Dendritic Cell Neoplasm; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute
Details
Anti-CD123 CAR T-cell therapy (Southwest Hospital)Phase 2 ClinicalThe Southwest Hospital of AMU
Leukemia; Leukemia, Myeloid
Details
CD33-CD123-CLL1 CART-T cell therapy (Hebei Taihe Chunyu Biotechnology)Phase 2 ClinicalHebei Tahoe Chunyu Biotechnology Co Ltd
Leukemia, Myeloid
Details
CAR-T Cells Targeting CD33/CD123 therapy(Essen Biotech)BAH244; BAH-244Phase 2 ClinicalEssen Biotech
Leukemia, Myeloid, Acute
Details
AZD-9829AZD9829; AZD-9829Phase 2 ClinicalAstrazeneca Plc
Hematologic Diseases; Hematologic Neoplasms; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes
Details
Anti Tim-3/CD123 CAR-T Cell Therapy(Xuzhou Medical University)Phase 2 ClinicalThe Affiliated Hospital Of Xuzhou Medical University, Xuzhou Medical University (Xzmu)
Leukemia, Myeloid, Acute
Details
MP0533MP0533Phase 2 ClinicalMolecular Partners Ag
Leukemia, Myeloid, Acute
Details
MipletamigAPVO-436; APVO436Phase 2 ClinicalAptevo
Leukemia, Myeloid, Acute; Myelodysplastic Syndromes
Details
Anti-CD123 CAR T-cell therapy (University of Pennsylvania/Novartis)JEZ-567Phase 1 ClinicalNovartis Pharma Ag, University Of Pennsylvania
Leukemia, Myeloid, Acute
Details
FlotetuzumabS-80880; MGD-006; RES-234Phase 1 ClinicalMacrogenics Inc
Blastic Plasmacytoid Dendritic Cell Neoplasm; Hematologic Neoplasms; Hodgkin Disease; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Hairy Cell; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Mastocytosis, Systemic; Neoplasms, Plasma Cell; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Details
UCART-123UCART-123; UCART-123v1.2Phase 1 ClinicalCellectis Sa
Blastic Plasmacytoid Dendritic Cell Neoplasm; Leukemia, Myeloid, Acute
Details
Anti-CD123 CAR T cell therapy (Shanghai GeneChem)Phase 1 ClinicalShanghai Genechem Co Ltd
Leukemia, Myeloid, Acute
Details
Anti-CD123 CAR T-cell therapy (Nanjing Legend Biotech)Phase 1 Clinical
Leukemia, Myeloid, Acute
Details
MB-102 (Mustang Bio)MB-102Phase 1 ClinicalCity Of Hope National Medical Center, Mustang Bio Inc
Blastic Plasmacytoid Dendritic Cell Neoplasm; Leukemia, Biphenotypic, Acute; Leukemia, Myeloid, Acute; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma
Details
ACLX-002ACLX-002Phase 1 ClinicalArcellx Inc
Leukemia, Myeloid, Acute; Myelodysplastic Syndromes
Details
MGD-024MGD-024Phase 1 ClinicalMacrogenics Inc
Blastic Plasmacytoid Dendritic Cell Neoplasm; Hodgkin Disease; Leukemia, B-Cell; Leukemia, Hairy Cell; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Neoplasms
Details
AFM-28AFM-28Phase 1 ClinicalAffimed
Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Neoplasms
Details
VIP943BAY-943; VIP-943Phase 1 ClinicalBayer AG
Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Details
Anti-CD123 LV redirected T cells Therapy (Childrens Hospital of Philadelphia)CART123Phase 1 ClinicalChildrens Hospital of Philadelphia
Leukemia, Myeloid, Acute
Details
JY-017JY017; JY-017Phase 1 ClinicalInstitute Of Hematology & Blood Diseases Hospital
Leukemia, Myeloid, Acute
Details
ACLX-004ACLX-004Phase 1 ClinicalArcellx Inc
Leukemia, Myeloid, Acute; Myelodysplastic Syndromes
Details
Donor-derived CD123-CD16 bispecific antibody-modified NK cells therapy(Chinese PLA General Hospital)Phase 1 ClinicalPla General Hospital
Leukemia, Myeloid, Acute
Details
Autologous CAR123 T lymphocytes cell tharapy(Institute of Hematology and Blood Transfusion, Czech Republic)Phase 1 ClinicalInstitute of Hematology and Blood Transfusion, Czech Republic
Blastic Plasmacytoid Dendritic Cell Neoplasm; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma
Details
Anti-CD123 CAR NK cells therapy(Chongqing Precision Biotechnology)Phase 1 ClinicalChongqing Precision Biotechnology Co Ltd
Leukemia, Myeloid, Acute; Neoplasms, Plasma Cell
Details
RJK-RT2831RJK-RT2831; RJKRT2831; RT-2831; RT2831Phase 1 ClinicalNanjing RegeneCore Biotech Co Ltd
Hematologic Neoplasms
Details
CD123 CAR-NK cell therapy(Beijing JD Biotech)JD123; JD-123Phase 1 ClinicalBeijing JD Biotech Co Ltd
Leukemia, Myeloid, Acute
Details
Universal CAR-T Cells therapy(Shenzhen Geno-Immune Medical Institute)Phase 1 ClinicalShenzhen Geno-Immune Medical Institute
Leukemia, Myeloid, Acute
Details
AVC-201AVC-201; Allo-RevCAR01-T-CD123Phase 1 ClinicalAvenCell Europe GmbH
Leukemia, Myeloid, Acute
Details
CD123-CAR T cells(St Jude Children's Research Hospital)Phase 1 ClinicalSt. Jude Children'S Research Hospital
Blastic Plasmacytoid Dendritic Cell Neoplasm; Myelodysplastic Syndromes; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma
Details
LAVA-1266LAVA1266; LAVA-1266Phase 1 ClinicalLava Therapeutics NV
Hematologic Neoplasms; Leukemia, Myeloid, Acute
Details
Allogenic CD123-CAR-NK Cells therapy(JD Biotech)JD023Phase 1 ClinicalBeijing JD Biotech Co Ltd, Chinese Academy Of Military Medical Sciences
Leukemia, Myeloid, Acute
Details
BYON-4413BYON-4413Phase 1 ClinicalByondis Bv
Hematologic Neoplasms; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes
Details
GR-1901GR1901; GR-1901Phase 1 ClinicalChongqing Genrix Biopharmaceutical Co Ltd, Genrix (Shanghai) Biopharmaceutical Co Ltd
Leukemia, Myeloid, Acute
Details
SQZ-622(Novartis Pharma)SQZ-622Phase 1 ClinicalNovartis Pharma Ag
Leukemia, Myeloid, Acute
Details
SAR-443579SAR-443579; SAR443579; SAR'579; IPH6101; IPH-6101Phase 1 ClinicalSanofi
Blastic Plasmacytoid Dendritic Cell Neoplasm; Hematologic Diseases; Leukemia, B-Cell; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma
Details
UniCAR02-TUniCAR02-TPhase 1 ClinicalCellex Patient Treatment Gmbh
Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Kidney Neoplasms; Prostatic Neoplasms
Details
IL3 CAR T-cell therapy (Yake Biotechnology)Phase 1 ClinicalZhejiang University
Leukemia, Myeloid, Acute
Details
Anti-CD123 chimeric antigen receptor T cell therapy (Yake Biotechnology)ClinicalShanghai YaKe Biotechnology Co Ltd
Leukemia, Myeloid, Acute
Details

Marketed Drug Information

English NameResearch CodeHighest Development StageCompanyFirst Brand NameFirst Approved CountryFirst IndicationFirst Approved CompanyFirst Approved DateIndicationClinical Trial
TagraxofuspSL-401; DTIL-3; DT388 IL3ApprovedTexas A&M University Development FoundationElzonrisUnited StatesBlastic Plasmacytoid Dendritic Cell NeoplasmStemline Therapeutics Inc2018-12-21
Blastic Plasmacytoid Dendritic Cell Neoplasm; Leukemia; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Lymphoma; Multiple Myeloma; Myelodysplastic Syndromes; Primary Myelofibrosis
Details
Customer Reviews
  • A***r2026-03-11
    We've always had a pleasure experience with AcroBio. Products are always top quality, quote requests come back super quick, and everyone is very kind. Great, great team to work with!
  • C***e2023-05-23
    We used Biotinylated Human IL-3 R alpha / CD123 Protein, Fc,Avitag™ (MALS verified) for a viral titer assay with Jurkat cells and received excellent results. We had a great experience ordering from the Acro biosystems website, which was easy to navigate. The reconstitution directions were very helpful and clear and each vial lasted for several experiments. The shipping was very quick and we look forward to ordering more products from Acro.
  • Y***a2022-05-10
    We received the product at a reasonably fast speed. We used this product in ELISA. The product is robust and of good quality. The characterization information was accurate, reliable, and valuable for further calculations.
  • E***z2022-04-22
    After struggling to express large quantities of this protein in-house, we ordered this product and used it as the bait in our antibody discovery pipeline and found to to be extremely high quality. We used this product in ELISA as well as BLI, and generated reproducible results. In addition, we found the batch biotinylation information to be accurate which was helpful for calculating inputs for experiments.
  • R***r2021-10-28
    We ordered this biotinylated recombinant CD123 protein from Acro while it was still under development. We were utilizing it to test CAR binding via flow cytometry. We contacted Acro and they were very helpful in being able to expedite the production of it for us to use. Since receiving it, we have not had any issues with it; it works beautifully and consistently on flow with very clean binding to streptavidin. The only reason I deducted a star from technical services was a slight lack of communication as far as when the product would be ready; it was still ready in a timely manner, but slightly behind schedule. However, they were very accommodating and helpful in getting us the protein quickly.