IL-17 RB Overview
Molecule Name
Interleukin-17 receptor B
Synonyms
IL-17 RB,Interleukin-17 receptor B,Interleukin-17 receptor B,Cytokine receptor-like 4,IL-17 receptor homolog 1,IL-17Rh1,IL17Rh1,Interleukin-17B receptor,IL-17B receptor,IL17RB,CRL4, EVI27, IL17BR
Drug Development Progress
Drugs in Clinical Trials1
Approved Drugs0
Highest Development StagePhase 2 Clinical
Target Synonym
IL-17 receptor B，IL-17RB，Cytokine receptor-like 4，IL-17 receptor homolog 1，IL-17Rh1，IL17Rh1，Interleukin-17B receptor，IL-17B receptor
Background
IL17RB (EVI27, IL17Rh1) is a single pass transmembrane receptor which belongs to IL17R family of cytokine receptors. It was found to be expressed in liver, brain, testis and lungs. The ligand for IL17RB is IL17E, also known as IL25. The five IL-17 receptors (IL17RA-IL17RE) exhibit considerable sequence divergence between one another, but all appear to contain extracellular domains composed of fibronectin type-III (FnIII) domains, and cytoplasmic SEF/IL-17R (SEFIR) domains that show loose homology to Toll/IL-1R (TLR) domains.
IL-17 RB Product List
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Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| SM-17 | SM-17; SM17 | Phase 2 Clinical | Sinomab Bioscience Ltd | Asthma; Dermatitis, Atopic; Idiopathic Pulmonary Fibrosis; Inflammatory Bowel Diseases | Details |