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IL-1 beta
IL-1 beta Overview
| English Name | Interleukin-1 beta | Approved Drugs | 10 |
| Drugs in Clinical Trials | 17 | Target Synonym | IL1-BETA，IL-1，Interleukin-1beta，IL-1B，IL-1β，IL-1 β，IL1beta，Interleukin 1beta，Catabolin，IL-1 beta，IL1B，Interleukin 1 Beta，IL1F2，Pro-Interleukin-1-Beta，Preinterleukin 1 Beta，Interleukin-1 Beta |
| Highest Development Stage | Approved | ||
| English Name | Interleukin-1 beta |
| Target Synonym | IL1-BETA，IL-1，Interleukin-1beta，IL-1B，IL-1β，IL-1 β，IL1beta，Interleukin 1beta，Catabolin，IL-1 beta，IL1B，Interleukin 1 Beta，IL1F2，Pro-Interleukin-1-Beta，Preinterleukin 1 Beta，Interleukin-1 Beta |
| Approved Drugs | 10 |
| Drugs in Clinical Trials | 17 |
| Highest Development Stage | Approved |
IL-1 beta Product List
- Product Category
Protein (8)Kits (2)
- Product Status
Launched (10)
- Species
Human (8)Mouse (1)Cynomolgus (1)
- Tag
Tag Free (3)Fc Tag (1)His Tag (3)His Tag & Avi Tag (1)- (2)
- Conjugate
Unconjugated (7)Biotin-labeled (1)- (2)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|---|
HOT CRS-B002 |  Human | - | Human IL-1β ELISA Kit | |||
HOT GMP-ILBH16 | Human | E. coli | GMP Human IL-1 beta Protein |  |  |  |
HOT ILB-H4110 | Human | E. coli | Human IL-1 beta / IL-1F2 Protein, premium grade |  | |  |
HOT ILB-H51H3 | Human | E. coli | Human IL-1 beta / IL-1F2 Protein, His Tag (MALS verified) |  | | |
HOT ILB-H82E9 | Human | HEK293 | Biotinylated Human IL-1 beta / IL-1F2 Protein, His,Avitag™ (MALS verified) |  | | |
HOT ILB-M51H3 |  Mouse | E. coli | Mouse IL-1 beta / IL-1F2 Protein, His Tag (MALS verified) |  | | |
CRS-A012 | Human | - | resDetect™ Human Interleukin-1 beta (IL-1 beta) ELISA Kit (Residue Testing) | |||
ILA-H525c | Human | HEK293 | Human IL-1 beta / IL-1F2 Protein, Fc Tag (MALS verified) |  | | |
ILB-H5113 | Human | E. coli | Human IL-1 beta / IL-1F2 Protein, Research Grade |  | | |
ILB-C51H3 |  Cynomolgus | E. coli | Cynomolgus IL-1 beta / IL-1F2 Protein, His Tag |  | |
Total: 10
- 1
IL-1 beta Background
Interleukin-1 beta (IL-1β) is also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1 beta.
IL1β are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL1α and IL1β are regulated independently, they bind to the same receptor and exert identical biological effects.
IL-1β is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
IL-1 beta Synonyms
IL1B,IL-1BETA,IL1F2,IL-1β
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Ensereptide | PXL-01 | Phase 3 Clinical | Promore Pharma | Cicatrix; Post-surgical adhesions; Tissue Adhesions | Details |
| Efprezimod alfa | CD24-Fc; HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110 | Phase 3 Clinical | Oncoimmune Inc | Coronavirus Disease 2019 (COVID-19); Dyslipidemias; Graft vs Host Disease; Hematopoietic stem cell transplantation (HSCT); HIV Infections; Leukemia; Leukemia, Myeloid, Acute; Melanoma; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Solid tumours | Details |
| Lutikizumab | ABT-981 | Phase 3 Clinical | Abbvie Inc | Colitis, Ulcerative; Crohn Disease; Dermatitis, Atopic; Hidradenitis Suppurativa; Osteoarthritis; Osteoarthritis, Knee | Details |
| Goflikicept | RPH-104 | Phase 3 Clinical | Trpharm | Arthritis, Gouty; Coronavirus Disease 2019 (COVID-19); Familial Mediterranean Fever; Gout; Pancreatitis; Pericarditis; Schnitzler Syndrome; ST Elevation Myocardial Infarction; Still's Disease, Adult-Onset | Details |
| KPL-387 | KPL-387 | Phase 3 Clinical | Kiniksa Pharmaceuticals Ltd | Heart Diseases; Pericarditis | Details |
| Canakinumab biosimilar (GENERIUM Pharmaceuticals) | GNR-086 | Phase 3 Clinical | Generium Pharmaceuticals | Arthritis, Juvenile; Still's Disease, Adult-Onset | Details |
| Arumakimig | MAS825; MAS-825 | Phase 3 Clinical | Novartis Pharmaceuticals Corp | Autoimmune Lymphoproliferative Syndrome; Coronary Disease; Coronavirus Disease 2019 (COVID-19); Enterocolitis; Still's Disease, Adult-Onset | Details |
| AVTX-009 | FL-101; AVTX-009; LY-2189102 | Phase 2 Clinical | Eli Lilly And Company | Arthritis, Rheumatoid; Autoimmune Diseases; Carcinoma, Non-Small-Cell Lung; Diabetes Mellitus, Type 2; Hidradenitis Suppurativa; Urinary Bladder Neoplasms | Details |
| CU-06 | CU-06-EYE; CU-06-IBD; CU-061004; Sac-1004; CU-06-ONCO; CU-06-HAE; CU06-1004 | Phase 2 Clinical | Curacle Co Ltd | Angioedemas, Hereditary; Colitis, Ulcerative; Crohn Disease; Diabetic macular oedema; Diabetic Retinopathy; Lung Diseases; Macular Degeneration; Myocardial Infarction; Neoplasms; Stroke | Details |
| ABBV-9832 | ABBV-9832 | Phase 2 Clinical | Abbvie Inc | Arthritis, Rheumatoid | Details |
| ABBV-166 | ABBV-166 | Phase 2 Clinical | Abbvie Inc | Arthritis, Psoriatic; Crohn Disease | Details |
| IL1-beta receptor antagonist Therapy(Hamlet BioPharma) | Phase 2 Clinical | Hamlet BioPharma AB | Cystitis; Pain | Details | |
| Gevokizumab | XMA-005.2; AB-7; XOMA-052; S-78989; VPM-087; XMA-0052 | Phase 1 Clinical | Xoma Corp | Acne Vulgaris; Arthritis, Rheumatoid; Behcet Syndrome; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Cryopyrin-Associated Periodic Syndromes; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Esophageal Neoplasms; Hereditary Autoinflammatory Diseases; Labyrinth Diseases; Osteoarthritis; Panuveitis; Pyoderma Gangrenosum; Stomach Neoplasms; Uveitis | Details |
| GenSci-161 | GenSci-161 | Phase 1 Clinical | Changchun GeneScience Pharmaceuticals Co Ltd | Endometriosis; Hidradenitis Suppurativa | Details |
| Diacerein ointment (TWi Biotechnology) | AC-203 | Phase 1 Clinical | Twi Biotechnology Inc | Epidermolysis Bullosa; Pemphigoid, Bullous | Details |
| DLX-2323 | DLX-2323 | Phase 1 Clinical | Delenex Therapeutics Ag | Inflammation | Details |
| Tavo-103 | Tavo103; Tavo-103; TAVO-103A; TAVO103A | Phase 1 Clinical | Tavotek Biotherapeutics (Hong Kong) Ltd | Details |
Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | Earliest Brand Name | Earliest Approval Country | Earliest Indication | Earliest Approval Company | Earliest Approval Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Canakinumab | ACZ-885 | Approved | Novartis Pharma Ag | Ilaris | United States | Muckle-Wells Syndrome (MWS); Cryopyrin-Associated Periodic Syndromes | Novartis Pharma Ag | 2009-06-17 | Alzheimer Disease; Anemia; Anemia, Sickle Cell; Aortic Aneurysm, Abdominal; Arthritis, Gouty; Arthritis, Juvenile; Arthritis, Rheumatoid; Atherosclerosis; Behcet Syndrome; Carcinoma, Non-Small-Cell Lung; Cardiovascular Diseases; Chronic Urticaria; Cognitive Dysfunction; Coronavirus Disease 2019 (COVID-19); Cryopyrin-Associated Periodic Syndromes; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Familial Mediterranean Fever; Gout; Hepatitis, Alcoholic; Hereditary Autoinflammatory Diseases; Hyperimmunoglobulin D syndrome; Inflammation; Lung Neoplasms; Mevalonate Kinase Deficiency; Muckle-Wells Syndrome (MWS); Mucocutaneous Lymph Node Syndrome; Muscular Dystrophy, Duchenne; Myelodysplastic Syndromes; Peripheral Arterial Disease; Polyarticular Juvenile Idiopathic Arthritis; Polycythemia Vera; Prediabetic State; Primary Myelofibrosis; Pulmonary Disease, Chronic Obstructive; Pyoderma Gangrenosum; Sarcoidosis, Pulmonary; Schnitzler Syndrome; Still's Disease, Adult-Onset; | Details |
| PG-201 | PG-201 | Approved | Viromed | Layla | South Korea | Osteoarthritis | Pmg Pharm Co Ltd | 2012-01-01 | Osteoarthritis; Osteoarthritis, Knee | Details |
| Edaravone/(+)-2-Decanol | SIM-071201 | Approved | Jiangsu Simcere Pharmaceutical Co Ltd | 三贝心, 三贝欣, 先必新, Sanbexin | Mainland China | Stroke | Nanjing Simcere Dongyuan Pharmaceutical Co Ltd | 2020-07-29 | Alzheimer Disease; Amyotrophic Lateral Sclerosis; Brain Infarction; Cerebral Hemorrhage; Cognition Disorders; Ischemic Stroke; Stroke | Details |
| Diacerein | KW-4800; SF-277; Art-50 | Approved | Cartivix, Fisiodar, Verboril, Art, 安必丁, Artrodar, Artrolyt | Coronavirus Disease 2019 (COVID-19); Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 2; Epidermolysis Bullosa; Insulin Resistance; Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Overweight | Details | |||||
| Firsekibart | GenSci-048; GenSci048 | Approved | Changchun GeneScience Pharmaceuticals Co Ltd | 金蓓欣 | Mainland China | Arthritis, Gouty | Changchun GeneScience Pharmaceuticals Co Ltd | 2025-06-30 | Arthritis, Gouty; Arthritis, Juvenile; Arthritis, Rheumatoid; Endometriosis; Gout; Lung Diseases, Interstitial; Pain; Solid tumours; Still's Disease, Adult-Onset; systemic sclerosis-associated interstitial lung disease | Details |
| Metaxalone (Primus Pharmaceuticals) | Approved | Primus Pharmaceuticals Inc | United States | Muscle Spasticity | Primus Pharmaceuticals Inc | 2015-06-01 | Muscle Spasticity | Details | ||
| Andrographolide/Sodium Hydrogen Sulfite | Approved | Bacterial Infections | Details | |||||||
| Edaravone/(+)-2-Decanol (Yantai Yene/Simcere) | Y-2 | Approved | Simcere Pharmaceutical Group Ltd, Yantai Yene Pharma Co Ltd | Mainland China | Stroke | Jiangsu Simcere Pharmaceutical Co Ltd | 2024-12-01 | Cerebral Hemorrhage; Cognitive Dysfunction; Intracranial Hemorrhages; Ischemic Stroke; Stroke | Details | |
| Rilonacept | KPL-914; RGN-303 | Approved | Regeneron Pharmaceuticals Inc | Arcalyst, 炎朵 | United States | Cryopyrin-Associated Periodic Syndromes | Kiniksa Pharmaceuticals Ltd | 2008-02-27 | Anemia; Arthritis, Juvenile; Atherosclerosis; Coronary Artery Disease; Cryopyrin-Associated Periodic Syndromes; Deficiency of interleukin-1 receptor antagonist; Diabetes Mellitus, Type 1; Familial Mediterranean Fever; Genetic Diseases, Inborn; Gout; Hearing Loss, Sensorineural; Inflammation; Muckle-Wells Syndrome (MWS); Pericarditis; Renal Insufficiency, Chronic; Sarcoidosis; Schnitzler Syndrome; Scleroderma, Diffuse; Scleroderma, Systemic; Still's Disease, Adult-Onset; Urticaria; Vascular Diseases | Details |
| Thalidomide | NSC-66847; NSC-527179; K-17; FPF-300; FPF300 | Approved | Celgene Corp | Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled | Mainland China | Leprosy, Lepromatous; Multiple Myeloma | Changzhou Pharmaceutical Factory | 1982-01-01 | Acquired Immunodeficiency Syndrome; Adenocarcinoma, Clear Cell; Adenoma, Islet Cell; Amyotrophic Lateral Sclerosis; Anemia, Refractory; Anemia, Refractory, with Excess of Blasts; Anemia, Sideroblastic; Angiodysplasia; Appendiceal Neoplasms; Arachnoiditis; Arteriovenous Malformations; Axial Spondyloarthritis; beta-Thalassemia; Burning Mouth Syndrome; Carcinoid Tumor; Carcinoma, Adenosquamous; Carcinoma, Hepatocellular; Cholangitis, Sclerosing; Colorectal Neoplasms; Cough; Endometrial Neoplasms; Endometriosis; Epilepsy; Erythema Nodosum; Gastric Antral Vascular Ectasia; Gastrointestinal Hemorrhage; Genetic Diseases, Inborn; Glioma; Graft vs Host Disease; Head and Neck Neoplasms; Hemoglobinopathies; HIV Infections; HIV Wasting Syndrome; Hodgkin Disease; Hormone-Resistant Prostate Neoplasms; Hypertension, Portal; Idiopathic Pulmonary Fibrosis; Kidney Neoplasms; Leiomyosarcoma; Leprosy, Lepromatous; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelomonocytic, Chronic; Liver Neoplasms; Lung Neoplasms | Details |
Product Reviews
k***r2023-06-27
0People Likeused this elisa as a control to compare against other methods of cytokine detection. quantification form both methods were similar and therefore the elisa worked well for our purpose.
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