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Hyaluronidase PH-20

Hyaluronidase PH-20 Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
Tag Free (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
PH0-H5219	Human	HEK293	Human Hyaluronidase PH-20 / SPAM1 Protein, Tag Free (active enzyme, MALS verified)

Total: 1

Hyaluronidase PH-20 Background

Hyaluronidase PH-20 is also known as Sperm adhesion molecule 1 (SPAM1) and Sperm surface protein PH-20, which belongs to the glycosyl hydrolase 56 family, SPAM1 / PH-20 is expressed in testis. SPAM-1 / PH20 random hydrolysis of (1->4)-linkages between N – acetyl – beta – D – glucosamine and D-glucuronate residues in hyaluronate. SPAM-1 / PH20 involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. SPAM1 aids in penetrating the layer of cumulus cells by digesting hyaluronic acid.

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
CNK-UT cells therapy		Phase 1 Clinical	Zhejiang University	Solid tumours	Details

Product Reviews

E***l2023-01-14
0People Like
Human Hyaluronidase PH-20 / SPAM1 Protein, Tag Free (active enzyme, MALS verified)
The timely fashion in which orders are completed and the quick access to a variety of products makes returning back to Acro a promising investment. Ordering the product PH0-H5219-200ug was a simple and easy task to complete, especially with Acro’s user-friendly website. Delivery of the items as well, with Acro, as long as the product is available it arrives in a timely fashion. I also like the way the items are packaged and that documentation can be found quickly for each product.