HSP90AA1 Overview
Molecule Name
Heat shock protein HSP 90-alpha
Synonyms
HSP90AA1,HSP90A,HSP 86,HSP86,HSPC1,HSPCA,EL52,HSP89A,HSP90N,HSPCAL1,HSPCAL4,HSPN,Hsp89,Hsp90,LAP2
Drug Development Progress
Drugs in Clinical Trials0
Approved Drugs1
Highest Development StageApproved
Target Synonym
Heat Shock Protein 90kDa Alpha (Cytosolic)， Class A Member 1，Heat Shock 90kDa Protein 1， Alpha，Heat Shock 90kD Protein 1， Alpha，HSP 86，HSP90A，HSPC1，Heat Shock Protein 90kDa Alpha Family Class A Member 1，Epididymis Secretory Sperm Binding Protein Li 65p，Epididymis Luminal Secretory Protein 52，Heat Shock 90kD Protein 1， Alpha-Like 4，Heat Shock 90kD Protein， Alpha-Like 4，HEL-S-65p，FLJ31884，HSPCAL1，HSPCAL4，HSP89A，HSP90N，Hsp103，Hsp89，Hsp90，EL52，HSPN，LAP2，Heat shock protein HSP 90-alpha，HSP86，LPS-associated protein 2，HSPCA，HSP90AA1，Heat Shock Protein 90 Alpha Family Class A Member 1，Renal carcinoma antigen NY-REN-38，Heat shock 86 kDa，Lipopolysaccharide-associated protein 2，LAP-2
Background
Heat shock protein HSP 90-alpha (HSP90AA1 or HSP90A) is also known as Heat shock 86 kDa (HSP 86 or HSP86), Renal carcinoma antigen NY-REN-38, HSPC1, HSPCA, EL52, HSP89A, HSP90N, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2, which belongs to the heat shock protein 90 family. HSP90AA1 undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. HSP90AA1 interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.
HSP90AA1 Product List
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Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | Earliest Brand Name | Earliest Approval Country | Earliest Indication | Earliest Approval Company | Earliest Approval Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Pimitespib | TAS-116 | Approved | Otsuka Pharmaceutical Co Ltd, Taiho Pharmaceutical Co Ltd | Jeselhy, ジェセリ | Japan | Gastrointestinal Stromal Tumors | Taiho Pharmaceutical Co Ltd | 2022-08-01 | Biliary Tract Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Esophageal Neoplasms; Gastrointestinal Stromal Tumors; Head and Neck Neoplasms; Sarcoma, Alveolar Soft Part; Solid tumours; Stomach Neoplasms | Details |