HLA-A*0201 & B2M & EBV EBNA (FMVFLQTHI)

HLA-A*0201, a prevalent MHC class I allele, assembles with β2-microglobulin (B2M) and the EBV EBNA peptide FMVFLQTHI to form a peptide-MHC complex. As a protein family expressed in EBV latent infection, EBNA preserves viral genome stability, modulates host cell cycle and enables immune evasion. It is tightly linked to EBV-associated disorders such as infectious mononucleosis and nasopharyngeal carcinoma, acting as a vital target for diagnosis and mechanistic studies. The surface-displayed complex can be recognized by CD8⁺ cytotoxic T cells, supporting research on EBV-specific immunity and immunotherapy development.