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HGF

HGF Overview

English Name	Hepatocyte growth factor	Approved Drugs	1
Drugs in Clinical Trials	7	Target Synonym	EC 3.4.21.7，Hepatocyte Growth Factor (Hepapoietin A; Scatter Factor)，EC 3.4.21，HGF，Hepatopoietin-A，Scatter factor，Hepatocyte Growth Factor (Hepapoietin A，Scatter Factor)，Fibroblast-Derived Tumor Cytotoxic Factor，Lung Fibroblast-Derived Mitogen，SF，Deafness， Autosomal Recessive 39，Hepatopoietin A，DFNB39，F-TCF，HGFB，Hepatocyte Growth Factor，HPTA
Highest Development Stage	Approved

English Name	Hepatocyte growth factor
Target Synonym	EC 3.4.21.7，Hepatocyte Growth Factor (Hepapoietin A; Scatter Factor)，EC 3.4.21，HGF，Hepatopoietin-A，Scatter factor，Hepatocyte Growth Factor (Hepapoietin A，Scatter Factor)，Fibroblast-Derived Tumor Cytotoxic Factor，Lung Fibroblast-Derived Mitogen，SF，Deafness， Autosomal Recessive 39，Hepatopoietin A，DFNB39，F-TCF，HGFB，Hepatocyte Growth Factor，HPTA
Approved Drugs	1
Drugs in Clinical Trials	7
Highest Development Stage	Approved

HGF Product List

Product Category
Protein (4)Kits (1)
Product Status
Launched (5)
Species
Human (5)
Tag
His Tag (1)Fc Tag (1)- (1)Tag Free (2)
Conjugate
Unconjugated (4)- (1)

Cat. No.	Species	Host	Product Description
HOT HGF-H5218	Human	HEK293	Human HGF Protein, premium grade
HOT HGF-H5253	Human	HEK293	Human HGF Protein, Fc Tag (MALS verified)
HOT HGF-H52H3	Human	HEK293	Human HGF Protein, His Tag, low endotoxin (MALS verified)
CRS-B012	Human	-	Human HGF ELISA Kit
GMP-HGFH28	Human	HEK293	GMP Human HGF Protein

Total: 5

HGF Background

Hepatocyte growth factor (HGF) is a paracrine cellular growth, motility and morphogenic factor. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. In addition, HGF has been implicated in a variety of cancers, including of the lungs, pancreas, thyroid, colon, and breast.

HGF Synonyms

HGF,HPTA,SF

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Fosgonimeton	NDX-1017; ATH-1017; ATH 1017	Phase 3 Clinical	M3 Biotechnology	Alzheimer Disease; Dementia; Lewy Body Disease; Parkinson Disease	Details
RGL-2102	RGL-2102; RGL2102	Phase 3 Clinical	Shanghai Regenelead Therapies Co Ltd	Diabetic Foot; Ischemia; Ulcer; Wound Infection	Details
Ficlatuzumab	AV-299; SCH-900105	Phase 3 Clinical	Aveo	Carcinoma, Basal Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cholangiocarcinoma; Colonic Neoplasms; Glioblastoma; Head and Neck Neoplasms; Leukemia, Myeloid, Acute; Liver Neoplasms; Lung Neoplasms; Lymphoma; Multiple Myeloma; Oropharyngeal Neoplasms; Pancreatic Neoplasms; Respiratory Tract Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck	Details
Umikibart	YYB-101; NOV-1105; CLM-101	Phase 2 Clinical	YooYoung Pharmaceutical Co Ltd	Colorectal Neoplasms; Solid tumours	Details
ATH-1020	ATH-1020	Phase 1 Clinical	Athira Pharma Inc	Nerve Degeneration	Details
ATH-1105	ATH-1105	Phase 1 Clinical	Athira Pharma Inc	Amyotrophic Lateral Sclerosis; Frontotemporal Dementia	Details
Microbiome-optimized autologous stem cell therapy (Biotech Holdings)		Clinical	Biotech Holdings	Peripheral Vascular Diseases	Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Beperminogene perplasmid	AMG-0001-01; AMG-0001; DS-992; TREAT-HGF	Approved	Anges Mg, Osaka University	Collategene	Japan	Peripheral Arterial Disease; Ischemia	Anges Inc, null	2019-03-01	Arterial Occlusive Diseases; Atherosclerosis; Foot Ulcer; Ischemia; Peripheral Arterial Disease; Peripheral Vascular Diseases; Ulcer; Vascular Diseases	Details