HABP1

HABP1

HABP1 Overview

Molecule Name
HLA-DR antigens-associated invariant chain
Synonyms
C1QBP,GC1QBP,HABP1,SF2P32,p33
Drug Development Progress
Drugs in Clinical Trials4
Approved Drugs0
Highest Development StagePhase 2 Clinical
Target Synonym
CLIP,CD74,Ia antigen-associated invariant chain,CD74 Molecule,CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex, Class II Antigen-Associated),CD74 Molecule, Major Histocompatibility Complex, Class II Invariant Chain,HLA-DR Antigens-Associated Invariant Chain,Ia-Associated Invariant Chain,MHC HLA-DR Gamma Chain,HLA-DR-Gamma,DHLAG,P33,CD74 Antigen,Ia-GAMMA,HLADG,II,Gamma Chain Of Class II Antigens,HLA Class II Histocompatibility Antigen Gamma Chain
Background
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP), a member of the MAM33 family, is also known as ASF/SF2-associated protein p32, glycoprotein gC1qBP (C1qBP), mitochondrial matrix protein p32 and hyaluronan-binding protein 1, which is a homotrimer that contains three monomers forming a donut-shaped structure with an unusually asymmetric charge distribution on the surface. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. C1QBP has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein. Furthermore, C1QBP has been shown to interact with Protein kinase D1, BAT2, PRKCD, PKC alpha and Protein kinase Mζ .

HABP1 Product List

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Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
S-227928S227928; S-227928Phase 2 ClinicalLes Laboratoires Servier
Hematologic Neoplasms; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Leukemia, Myeloid, Acute
Details
Influenza A M1 vaccine (Pascal Biosciences)Phase 1 ClinicalPascal Biosciences
Influenza A virus infections
Details
adenovector based vaccine (Pascal Biosciences/University of British Columbia)Phase 1 Clinical
Influenza A virus infections
Details
Bezetabart debotansineSTRO-001; SP7675; SP-7675; BN-301Phase 1 ClinicalSutro Biopharma Inc
Lymphoma, B-Cell; Hematologic Neoplasms; Lymphoma, Large B-Cell, Diffuse; Multiple Myeloma; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin
Details