Herpes simplex virus type 2 (HSV-2) is the primary cause of genital herpes. Glycoprotein B (gB) is a highly conserved, essential envelope protein that mediates viral fusion and entry into host cells. Because of its critical role in infection, gB is a prime target for neutralizing antibodies. High-affinity anti-gB antibodies are crucial for viral diagnostics, antiviral research, and vaccine development.