GDNF

GDNF Overview

English Name	Glial cell line-derived neurotrophic factors	Approved Drugs	0
Drugs in Clinical Trials	5	Target Synonym	Glial Cell Line-Derived Neurotrophic Factors
Highest Development Stage	NDA/BLA

English Name	Glial cell line-derived neurotrophic factors
Target Synonym	Glial Cell Line-Derived Neurotrophic Factors
Approved Drugs	0
Drugs in Clinical Trials	5
Highest Development Stage	NDA/BLA

GDNF Product List

Product Category
Protein (5)Kits (1)
Product Status
Launched (6)
Species
Human (5)Mouse (1)
Tag
Tag Free (4)His Tag (1)- (1)
Conjugate
Unconjugated (5)- (1)

Cat. No.	Species	Host	Product Description	Order Now
GDF-H5118	Human	E. coli	Human GDNF / ATF / hGDNF Protein (E. coli), premium grade	Add to Cart
GDF-H5119	Human	E. coli	Human GDNF / ATF / hGDNF Protein (E. coli), Research Grade	Add to Cart
GDF-H5219	Human	HEK293	Human GDNF / ATF / hGDNF Protein, premium grade	Add to Cart
GMP-GDFH17	Human	E. coli	GMP Human GDNF Protein (E. coli)	Add to Cart
RES-A117	Human	-	resDetect™ GDNF ELISA kit (Residue Testing)	Add to Cart
GDF-M5245	Mouse	HEK293	Mouse GDNF / ATF Protein, His Tag, low endotoxin (MALS verified)	Add to Cart

Total: 6

GDNF Background

Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily. The GDNF family members (consists of GDNF, neurturin, artemin and persephin) are structurally similar to transforming growth factor-beta. Unlike other members of the TGF-beta superfamily, which signal through the receptor serine-threonine kinases, GDNF family ligands activate intracellular signalling cascades via the receptor tyrosine kinase Ret. GDNF family ligands binds to GDNF family receptor alpha (GFRalpha) and then the GDNF family ligand-GFR alpha complex binds to and stimulates autophosphorylation of Ret.

GDNF Synonyms

GDNF,ATF

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
AB-1005	AMT-140; AB-1005; AAV2-GDNF; AAV2-GDNF-MSA; AAV2-GDNF-PD	Phase 2 Clinical	Uc San Francisco	Multiple System Atrophy; Parkinson Disease	Details
NRO-1	NRO-1; SI-01	Phase 2 Clinical	Senju Pharmaceutical Co Ltd	Xerophthalmia	Details
Ifezuntirgene inilparvovec	AAV5-miSNP15; AMT-130; AAV5-miHtt12; AAV5-miSNP7	Phase 2 Clinical	Amsterdam Molecular Therapeutics, Uniqure	Huntington Disease	Details
AAV2-GDNF gene therapy (NINDS)		Phase 1 Clinical	National Institute Of Neurological Disorders And Stroke	Parkinson Disease	Details
RGL-193	RGL-193	Phase 1 Clinical	Shanghai Regenelead Therapies Co Ltd	Parkinson Disease	Details

Product Reviews

P***i2025-05-13
0People Like
Human GDNF / ATF / hGDNF Protein, premium grade
Acro Biosystems' GDNF recombinant protein has proven to be a reliable and high-quality reagent for research focused on neuronal development and maturation. In my study involving cortical projection neuron cultures, GDNF consistently supported neuronal survival, neurite outgrowth, and the expression of maturation markers. Its batch-to-batch consistency and biological activity have made it an essential component in our differentiation protocols. I highly recommend this product to laboratories engaged in both fundamental neuroscience research and translational studies aiming to model neurodegenerative diseases or explore neuroprotective strategies.