GDF-2

GDF-2 Overview

English Name	Growth/differentiation factor 2	Approved Drugs	0
Drugs in Clinical Trials	1	Target Synonym	GDF-2，BMP-9，BMP9，HHT5，Bone Morphogenetic Protein 9
Highest Development Stage	Phase 2 Clinical

English Name	Growth/differentiation factor 2
Target Synonym	GDF-2，BMP-9，BMP9，HHT5，Bone Morphogenetic Protein 9
Approved Drugs	0
Drugs in Clinical Trials	1
Highest Development Stage	Phase 2 Clinical

GDF-2 Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
Tag Free (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature	Order Now
GD2-H5211	Human	HEK293	Human GDF-2 Protein, Tag Free				Add to Cart

Total: 1

GDF-2 Background

Human Growth and differentiation factor 2 (GDF-2), also known as Bone morphogenetic protein 9 (BMP-9), is a member of the BMP subgroup of the TGF-beta superfamily proteins that signal through heterodimeric complexes composed of type I and type II BMP receptors. GDF-2 Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. ALK1 is a signalling receptor for bone morphogenetic protein-9 (BMP-9) in endothelial cells (ECs). BMP-9 bound with high affinity to ALK1 and endoglin, and weakly to the type-I receptor ALK2 and to the BMP type-II receptor (BMPR-II) and activin type-II receptor (ActR-II) in transfected COS cells. Binding of BMP-9 to ALK2 was greatly facilitated when BMPR-II or ActR-II were co-expressed.