GAD2

GAD2 Overview

English Name	Glutamate decarboxylase 2	Approved Drugs	0
Drugs in Clinical Trials	1	Target Synonym	EC 4.1.1.15，GAD65，Glutamate Decarboxylase 2 (Pancreatic Islets And Brain， 65kD)，Glutamate Decarboxylase-2 (Pancreas)，EC:4.1.1.15，EC 4.1.1，Glutamate decarboxylase 65 kDa isoform，65 kDa glutamic acid decarboxylase，GAD2，Glutamate Decarboxylase 2，Glutamate Decarboxylase 2 (Pancreatic Islets And Brain， 65kDa)，GAD-65
Highest Development Stage	Pending

English Name	Glutamate decarboxylase 2
Target Synonym	EC 4.1.1.15，GAD65，Glutamate Decarboxylase 2 (Pancreatic Islets And Brain， 65kD)，Glutamate Decarboxylase-2 (Pancreas)，EC:4.1.1.15，EC 4.1.1，Glutamate decarboxylase 65 kDa isoform，65 kDa glutamic acid decarboxylase，GAD2，Glutamate Decarboxylase 2，Glutamate Decarboxylase 2 (Pancreatic Islets And Brain， 65kDa)，GAD-65
Approved Drugs	0
Drugs in Clinical Trials	1
Highest Development Stage	Pending

GAD2 Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
His Tag (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature	Order Now
GA2-H55H3	Human	InsectCells	Human GAD2 / GAD65 Protein, His Tag				Add to Cart

Total: 1

GAD2 Background

Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to gamma-aminobutyric acid (GABA), the major inhibitory transmitter in higher brain regions, and putative paracrine hormone in pancreatic islets. GAD uses pyridoxal-phosphate (PLP) as a cofactor.Two molecular forms of GAD (65 kDa and 67 kDa) are highly conserved and both are expressed in the CNS, pancreatic islet cells, testis, oviduct and ovary. The isoforms are regionally distributed cytoplasmically in the brains of rats and mice. GAD65 is an ampiphilic, membrane-anchored protein (585 a.a.), and is responsible for vesicular GABA production. GAD67 is cytoplasmic (594 a.a.), and seems to be responsible for significant cytoplasmic GABA production.