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Frizzled-5

Frizzled-5 Overview

English Name	Frizzled-5	Approved Drugs	0
Drugs in Clinical Trials	1	Target Synonym	Frizzled Class Receptor 5，C2orf31，HFZ5，Frizzled 5， Seven Transmembrane Spanning Receptor，Frizzled Family Receptor 5，Fz-5，FzE5，Seven-Transmembrane Receptor Frizzled-5，Chromosome 2 Open Reading Frame 31，Frizzled (Drosophila) Homolog 5，HFz5
Highest Development Stage	Phase 1 Clinical

English Name	Frizzled-5
Target Synonym	Frizzled Class Receptor 5，C2orf31，HFZ5，Frizzled 5， Seven Transmembrane Spanning Receptor，Frizzled Family Receptor 5，Fz-5，FzE5，Seven-Transmembrane Receptor Frizzled-5，Chromosome 2 Open Reading Frame 31，Frizzled (Drosophila) Homolog 5，HFz5
Approved Drugs	0
Drugs in Clinical Trials	1
Highest Development Stage	Phase 1 Clinical

Frizzled-5 Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
Fc Tag (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
FZ5-H5259	Human	HEK293	Human Frizzled-5 / FZD5 Protein, Fc Tag (MALS verified)

Total: 1

Frizzled-5 Background

Frizzled-5 (FZD5) is also known as FzE5, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD5 contains one FZ (frizzled) domain. FZD5 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD5 interacts specifically with Wnt5A to induce the beta-catenin pathway. FZD5 interacts with GOPC.

Frizzled-5 Synonyms

FZD5,Frizzled-5,C2orf31,,Fz-5,hFz5,FzE5

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Vantictumab	OMP-18R5; anti-Fzd7	Phase 1 Clinical	Bayer AG, Oncomed Pharmaceuticals Inc	Carcinoma, Non-Small-Cell Lung; Metastatic breast cancer; Osteopetrosis; Pancreatic Neoplasms; Solid tumours	Details