EMMPRIN

EMMPRIN Overview

English Name	Basigin	Approved Drugs	1
Drugs in Clinical Trials	4	Target Synonym	BSG，Extracellular matrix metalloproteinase inducer，UNQ6505/PRO21383，Basigin (Ok Blood Group)，Tumor Cell-Derived Collagenase Stimulatory Factor，Leukocyte Activation Antigen M6，Collagenase Stimulatory Factor，Basigin，5F7，Ok Blood Group，CD147 Antigen，EMPRIN，CD147，OK，TCSF，EMMPRIN，SLC7A11，OK blood group antigen
Highest Development Stage	Approved

English Name	Basigin
Target Synonym	BSG，Extracellular matrix metalloproteinase inducer，UNQ6505/PRO21383，Basigin (Ok Blood Group)，Tumor Cell-Derived Collagenase Stimulatory Factor，Leukocyte Activation Antigen M6，Collagenase Stimulatory Factor，Basigin，5F7，Ok Blood Group，CD147 Antigen，EMPRIN，CD147，OK，TCSF，EMMPRIN，SLC7A11，OK blood group antigen
Approved Drugs	1
Drugs in Clinical Trials	4
Highest Development Stage	Approved

EMMPRIN Product List

Product Category
Protein (6)
Product Status
Launched (6)
Species
Human (4)Mouse (1)Cynomolgus (1)
Tag
His Tag (3)Fc Tag (1)His Tag & Avi Tag (2)
Conjugate
Unconjugated (3)Biotin-labeled (2)FITC Labeled (1)

Cat. No.	Species	Host	Product Description	Order Now
HOT CD7-H5222	Human	HEK293	Human EMMPRIN / CD147 Protein, His Tag (MALS verified)	Add to Cart
HOT CD7-H82E0	Human	HEK293	Biotinylated Human EMMPRIN / CD147 Protein, Avitag™,His Tag (MALS verified)	Add to Cart
HOT CD7-M82E8	Mouse	HEK293	Biotinylated Mouse EMMPRIN / CD147 Protein, His,Avitag™ (MALS verified)	Add to Cart
CD7-H5259	Human	HEK293	Human EMMPRIN / CD147 Protein, Fc Tag	Add to Cart
CD7-HF222	Human	HEK293	FITC-Labeled Human EMMPRIN / CD147 Protein, His Tag	Add to Cart
CD7-C52H8	Cynomolgus	HEK293	Cynomolgus EMMPRIN / CD147 Protein, His Tag (MALS verified)	Add to Cart

Total: 6

EMMPRIN Background

CD147, also known as Basigin (BSG), or extracellular matrix metalloproteinase inducer (EMMPRIN). The human basigin protein contains 269 amino acids that form two heavily glycosylated C2 type immunoglobulin-like domains at the N-terminal extracellular portion. A second form of basigin has also been characterized that contains one additional immunoglobulin-like domain in its extracellular portion. As members of the immunoglobulin superfamily play fundamental roles in intercellular recognition involved in various immunologic phenomena, differentiation, and development, basigin is thought also to play a role in intercellular recognition and regulate several distinct functions, such as spermatogenesis, expression of the monocarboxylate transporter and the responsiveness of lymphocytes. Basigin is a type I integral membrane receptor that has many ligands, including the cyclophilin (CyP) proteins Cyp-A and CyP-B and certain integrins.

EMMPRIN Synonyms

Basigin,BSG,5F7,CD147,EMMPRIN,M6,OK,TCSF

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Mertuzumab		Phase 3 Clinical	Institute Of Medicine Fourth Military Medical University, Jiangsu Pacific Minok Biopharmaceutical Co., Ltd.	Carcinoma, Non-Small-Cell Lung; Coronavirus Disease 2019 (COVID-19)	Details
Meplazumab	HI6H8	Phase 3 Clinical	Institute Of Medicine Fourth Military Medical University, Jiangsu Pacific Minok Biopharmaceutical Co., Ltd.	Coronavirus Disease 2019 (COVID-19); Malaria; Malaria, Falciparum; Post-Acute COVID-19 Syndrome	Details
humanized ADCC cHAb18 antibody (Pacific Meinuoke/Fourth Military Medical University)		Phase 1 Clinical	Air Force Medical University	Carcinoma, Non-Small-Cell Lung	Details
CD147-CAR T cell therapy (Peking University People's Hospital)		Phase 1 Clinical	Peking University People'S Hospital	Lymphoma, T-Cell	Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Iodine[131I] Metuximab		Approved	Chengdu Huasun Biotechnology Co Ltd	Licartin, 利卡汀	Mainland China	Carcinoma, Hepatocellular	Chengdu Huasun Biotechnology Co Ltd	2006-10-12	Carcinoma, Hepatocellular	Details