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CD38

CD38

CD38 Overview

Molecule Name
Lymphocyte differentiation antigen CD38
Synonyms
CD38,T10,cADPr hydrolase 1
Drug Development Progress
Drugs in Clinical Trials48
Approved Drugs3
Highest Development StageApproved
Target Synonym
EC:3.2.2.6，EC:2.4.99.20，2-Phospho-Cyclic-ADP-Ribose Transferase，Cyclic ADP-Ribose Hydrolase 1，2-Phospho-ADP-Ribosyl Cyclase，NAD(+) Nucleosidase，CD38 Antigen (P45)，2-Phospho-ADP-Ribosyl Cyclase/2-Phospho-Cyclic-ADP-Ribose Transferase，Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase，ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 1，Cluster Of Differentiation 38，CD38 Antigen，EC 2.4.99.20，EC 3.2.2.6，ADPRC1，T10，2'-phospho-ADP-ribosyl cyclase，ADPRC 1，cADPr hydrolase 1，ADP-ribosyl cyclase 1，2'-phospho-cyclic-ADP-ribose transferase，CD38，CD38 Molecule，2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
Background
CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.

CD38 Product List

Species
  • Human（8）
  • Cynomolgus（1）
  • Mouse（1）
  • Rabbit（1）
  • Rat（1）
Tag
  • His Tag（6）
  • Fc Tag（2）
  • Avi Tag（1）
  • Fc Tag & Avi Tag（1）
  • His Tag & Avi Tag（1）
  • Mouse IgG Fc Tag（1）
Host
  • HEK293（12）
Conjugate
  • Unconjugated（7）
  • Biotin-labeled（3）
  • FITC Labeled（2）
Grade
  • RUO（12）
Low Endotoxin
  • Yes（3）
  • No（9）
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&Price
CD38
HOTAIDD‑Ready
CD8-H5224
Human CD38 Protein, His Tag, low endotoxin (Mass Spec & MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISASPRFlow

$455.00

50ug
CD38
HOT
CD8-H5255
Human CD38 Protein, Fc Tag, low endotoxin (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISAFlow

$300.00

50ug
CD38
HOT
CD8-HF2H5
FITC-Labeled Human CD38 Protein, His Tag (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISAFlow

$330.00

25ug
CD38
HOTAvitag
CD8-H82E7
Biotinylated Human CD38 Protein, Avitag™,His Tag (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISAFlow

$260.00

25ug
CD38
CD8-C5223
Cynomolgus CD38 Protein, His Tag (MALS verified)
Cynomolgus
HEK293
MALSSDS-PAGE
ELISA

$360.00

100ug
CD38
CD8-H5253
Human CD38 Protein, Mouse IgG2a Fc Tag, low endotoxin
Human
HEK293
SDS-PAGE
ELISAFlow

$360.00

50ug
CD38
Avitag
CD8-H8214
Biotinylated Human CD38 Protein, Avitag™
Human
HEK293
SDS-PAGE
ELISAFlow

$390.00

25ug
CD38
Avitag
CD8-H82F5
Biotinylated Human CD38 Protein, Fc,Avitag™ (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISAFlow

$360.00

25ug
CD38
CD8-HF255
FITC-Labeled Human CD38 Protein, Fc Tag
Human
HEK293
SDS-PAGE
ELISAFlow

$330.00

25ug
CD38
CD8-M5223
Mouse CD38 Protein, His Tag (MALS verified)
Mouse
HEK293
MALSSDS-PAGE

$360.00

100ug
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Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
MezagitamabTAK-079Phase 3 ClinicalTakeda Pharmaceutical Co Ltd
Autoimmune Diseases; Glomerulonephritis; Glomerulonephritis, IGA; Kidney Diseases; Lupus Erythematosus, Systemic; Multiple Myeloma; Myasthenia Gravis; Nephrosis; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia
Details
Daratumumab biosimilar (Celltrion)CT-P44Phase 3 ClinicalCelltrion Inc
Multiple Myeloma
Details
Daratumumab biosimilar (Biocad)BCD-264Phase 3 ClinicalBIOCAD JSC
Multiple Myeloma
Details
SCTC-21-CSCTC21C; SCTC-21-C; SCT-C21CPhase 3 ClinicalSinoCelltech Ltd
Amyloidosis; Autoimmune Diseases; Glomerulonephritis, IGA; Hematologic Neoplasms; Immunoglobulin Light-chain Amyloidosis; Lupus Erythematosus, Systemic; Multiple Myeloma
Details
Daratumumab biosimilar (Henlius)HLX-15Phase 3 Clinical
Multiple Myeloma
Details
Recombinant anti-CD38 fully human monoclonal antibody (Henlius Biotech)Phase 3 Clinical
Amyloidosis; Multiple Myeloma
Details
Recombinant human anti-CD38 momoclonal antibody(Sumgen)SG-301; SG301Phase 3 ClinicalHangzhou Shangjian Biotechnology Co Ltd
Hematologic Neoplasms; Lupus Erythematosus, Systemic; Multiple Myeloma; Nephrotic Syndrome
Details
STI-6129STI-6129; LNDS-1001Phase 2 ClinicalSorrento Therapeutics Inc
Immunoglobulin Light-chain Amyloidosis; Leukemia, Myeloid, Acute; Multiple Myeloma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Solid tumours
Details
Modakafusp alfaTEV-48573; TAK-573Phase 2 ClinicalTakeda Pharmaceutical Co Ltd
Melanoma; Multiple Myeloma; Neoplasms
Details
CLL1/CD33/CD38/CD7 CAR-T cell therapyPhase 2 ClinicalGuangzhou Bio-Gene Technology Co Ltd
Leukemia, Myeloid, Acute
Details
Anti-CD38 Monoclonal Antibody (Genrix)Phase 2 ClinicalGenrix (Shanghai) Biopharmaceutical Co Ltd
Multiple Myeloma
Details
4SCAR-T cell therapy (Shenzhen Geno-Immune Medical Institute)4SCAR-TPhase 2 ClinicalShenzhen Geno-Immune Medical Institute
Autoimmune Diseases; Hematologic Neoplasms; Neuroblastoma
Details
REGN-7945REGN7945; REGN-7945Phase 2 ClinicalRegeneron Pharmaceuticals Inc
Multiple Myeloma
Details
Anti-CD38 Antibody(Institute of Hematology & Blood Diseases Hospital)Phase 2 ClinicalInstitute Of Hematology & Blood Diseases Hospital
Antiphospholipid Syndrome; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia
Details
CID-103TSK011010; CID-103Phase 2 ClinicalTusk Therapeutics Ltd
Multiple Myeloma; Purpura, Thrombocytopenic, Idiopathic; Rejection of renal transplantation; Thrombocytopenia
Details
BHV-1100KP-1237; BHV-1100Phase 2 ClinicalBiohaven Pharmaceuticals Inc, Kleo Pharmaceuticals, PeptiDream Inc
Multiple Myeloma
Details
LumrotatugCM-313Phase 2 ClinicalKeymed Biosciences Co Ltd
Anemia; Anemia, Aplastic; Blood Platelet Disorders; Glomerulonephritis, IGA; Hematologic Neoplasms; Lupus Erythematosus, Systemic; Lymphoma; Multiple Myeloma; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia
Details
89Zr-DFO-daratumumabPhase 2 ClinicalMemorial Sloan Kettering Cancer Center
Multiple Myeloma
Details
64Cu-DOTA-daratumumabPhase 1 ClinicalCity Of Hope National Medical Center
Multiple Myeloma
Details
SAR-442257SAR-442257Phase 1 ClinicalSanofi
Neoplasms
Details
Anti-BCMA anti-CD38 bispecific chimeric antigen receptor T cell therapy (Shengyan Pharmaceutical Technology)Phase 1 ClinicalShengyan Pharmaceutical Technology
Multiple Myeloma
Details
dual anti-BCMA/anti-CD38 CAR T-cell therapy (Shengyan Pharmaceutical Technology/Tongji Medical College)Phase 1 ClinicalTongji Medical College
Multiple Myeloma
Details
CD38 CAR T-cellsPhase 1 ClinicalZhejiang University
Hematologic Neoplasms; Leukemia, Myeloid, Acute
Details
anti-CD38 CAR T-cell therapy (Shanghai Unicar-Therapy Bio-Medicine Technology/Soochow University/East China Normal University)Phase 1 ClinicalSoochow University
Leukemia, Myeloid, Acute
Details
actinium-225 labeled daratumumab (Actinium Pharmaceuticals)Phase 1 ClinicalActinium Pharmaceuticals Inc, City Of Hope National Medical Center, National Cancer Institute
Hematologic Neoplasms; Multiple Myeloma
Details
T-007 (TNK Therapeutics/Celularity)Phase 1 ClinicalTnk Therapeutics Inc
Multiple Myeloma
Details
Anti-CD38 chimeric antigen receptor T cell therapy(Yake Biotechnology)CAR-T CD-38Phase 1 ClinicalShanghai YaKe Biotechnology Co Ltd
Leukemia, Myeloid, Acute; Multiple Myeloma
Details
Indium In 111-DOTA-DaratumumabPhase 1 ClinicalCity Of Hope National Medical Center
Leukemia, Myeloid, Acute; Multiple Myeloma; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma
Details
Daratumumab biosimilar (Jushi Biopharma)Phase 1 ClinicalJushi Biopharmaceutical Co Ltd
Multiple Myeloma
Details
CD38\CS1 Chimeric Antigen Receptor T Cells therapy(The Second Hospital Of Shandong University)Phase 1 ClinicalThe Second Hospital Of Shandong University
Multiple Myeloma
Details
SAR-444559SAR444559; SAR-444559Phase 1 ClinicalSanofi
Inflammation
Details
68Ga-NB-38168Ga-NB381; 68Ga-NB-381; 18F-FDG(The First Affiliated Hospital Of Beijing University)Phase 1 ClinicalThe First Affiliated Hospital Of Beijing University
Multiple Myeloma
Details
Dual CLL1/CD38 targeting CAR-T cell therapy (Gracell Biotechnologies)Phase 1 ClinicalGracell Biotechnologies (Shanghai) Co Ltd
Leukemia, Myeloid, Acute
Details
Universal CAR-T Cells therapy(Shenzhen Geno-Immune Medical Institute)Phase 1 ClinicalShenzhen Geno-Immune Medical Institute
Leukemia, Myeloid, Acute
Details
RB-0021RB0021; RB-0021Phase 1 ClinicalRuiyang (Suzhou) Biological Technology Co Ltd
Hematologic Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Multiple Myeloma
Details
KJ-C2320KJ-C2320Phase 1 ClinicalCARsgen Therapeutics Holdings Ltd
Leukemia, Myeloid, Acute
Details
Daratumumab biosimilar (Hangzhou Jiuyuan Gene Engineering)JY43; JY-43Phase 1 ClinicalHangzhou Jiuyuan Gene Biomedical Co Ltd
Multiple Myeloma
Details
KYS202002AKYS-202002A; KYS202002APhase 1 ClinicalJiangsu Kanion Pharmaceutical Co Ltd
Lupus Erythematosus, Systemic; Multiple Myeloma
Details
ISB-2001ISB-2001; ABBV-2001Phase 1 ClinicalIchnos Sciences Sa
Multiple Myeloma
Details
TNB-738TNB-738Phase 1 ClinicalTeneoFour Inc
Details
GBR-1342GBR-1342; ISB-1342Phase 1 ClinicalGlenmark Pharmaceuticals Ltd
Multiple Myeloma
Details
XmAb-968XmAb968Phase 1 ClinicalXencor Inc
Hematologic Neoplasms; Leukemia, Promyelocytic, Acute
Details
XmAb-18968XmAb-18968Phase 1 ClinicalThe Medical College Of Wisconsin Nonprofit
Leukemia, Myeloid, Acute
Details
211At-OKT10-B10Phase 1 ClinicalFred Hutchinson Cancer Research Center
Multiple Myeloma
Details
Y-150(Wuhan Yzy Biopharma/CSPC Pharmaceutical)Y-150; Y150Phase 1 ClinicalCSPC Pharmaceutical Group Ltd, Wuhan Yzy Biopharma Co Ltd
Multiple Myeloma
Details
Anti CD38 chimeric antigen receptor T-cell therapy (Sorrento Therapeutics)Phase 1 ClinicalCelularity Inc, Sorrento Therapeutics Inc
Multiple Myeloma
Details
SAR-442085SAR-442085Phase 1 ClinicalSanofi
Multiple Myeloma
Details
111Indium labeled daratumumabCity Of Hope National Medical Center, National Cancer Institute
Details

Marketed Drug Information

English NameResearch CodeHighest Development StageCompanyFirst Brand NameFirst Approved CountryFirst IndicationFirst Approved CompanyFirst Approved DateIndicationClinical Trial
Daratumumab/Hyaluronidase-fihjDARA-PH20ApprovedJohnson & Johnson Innovative MedicineDarzalex Faspro, Darzquro, DARZALEX FASPRO, DARZALEX-SCUnited StatesMultiple MyelomaJanssen Biotech Inc2020-05-01
Amyloidosis; Anemia, Aplastic; Bone marrow transplant rejection; Hematologic Neoplasms; Hodgkin Disease; Immunoglobulin Light-chain Amyloidosis; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, Non-Hodgkin; Monoclonal Gammopathy of Undetermined Significance; Multiple Myeloma; Myelodysplastic Syndromes; Peripheral Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Rejection in heart transplantation; Smoldering Multiple Myeloma
Details
IsatuximabSAR-650984; hu38SB19ApprovedImmunogen IncSarclisaUnited StatesMultiple MyelomaSanofi-Aventis U.S. Llc2020-03-02
Amyloidosis; Anemia, Aplastic; Anemia, Hemolytic, Autoimmune; Carcinoma, Non-Small-Cell Lung; Constipation; Diarrhea; Gastrointestinal Hemorrhage; Goiter, Nodular; Hematologic Neoplasms; Hepatomegaly; Hodgkin Disease; Immunoglobulin Light-chain Amyloidosis; Leukemia, Myeloid, Acute; Leukemia, Plasma Cell; Leukemia, T-Cell; Lymphadenopathy; Lymphoma; Lymphoma, Non-Hodgkin; Macroglossia; Multiple Myeloma; Nausea; Neoplasms; Paraproteinemias; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Purpura; Satiety Response; Smoldering Multiple Myeloma
Details
DaratumumabJNJ-54767414ApprovedJohnson & Johnson Innovative MedicineDarzalex, 兆珂, 兆珂速United StatesMultiple MyelomaJanssen Biotech Inc2015-11-16
Alzheimer Disease; Amyloidosis; Anemia, Aplastic; Autoimmune Diseases; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Genital Neoplasms, Male; Glioblastoma; Glomerulonephritis; Hemangioma, Cavernous, Central Nervous System; Hodgkin Disease; Hypersensitivity; Immunoglobulin Light-chain Amyloidosis; Kidney Neoplasms; Leukemia, Myeloid, Acute; Lupus Erythematosus, Systemic; Lymphoma; Lymphoma, Extranodal NK-T-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, Primary Effusion; Multiple Myeloma; Myelodysplastic Syndromes; Paraproteinemias; POEMS Syndrome; Prostatic Neoplasms; Purpura, Thrombocytopenic, Idiopathic; Rejection of renal transplantation; Rejection of organ transplantation; Renal Insufficiency; Skin Diseases; Smoldering Multiple Myeloma; Stevens-Johnson Syndrome; Urologic Neoplasms; Waldenstrom Macroglobulinemia
Details
Customer Reviews
  • Y***u2023-03-31
    Biotinylated Human CD38 Protein, Avitag™,His Tag (MALS verified)
    This product can be used at < 0.4 ug/ml as a detection agent to quantify anti CD38 antibodies in a binding assay. Anti CD38 antibodies in either bovine serum albumin based sample diluent or murine serum can be detected by this production without a problem. Specific signals from the subsequent streptavidin conjugated enzyme reaction were very strong and very low noise from the negative control antibody group.
  • Y***u2023-03-16
    Mouse CD38 Protein, His Tag (MALS verified)
    Used 3 ug/ml of this protein as the capture antigen in an ELISA assay to screen for anti-mouse CD38 mAbs. Very strong signal from the positive control anti-mouse CD38 mAb (clone: NIMR5) and no binding to several anti-human CD38 mAbs or the anti-IgG secondary Ab in the assay. The "ETD of in-stock products: 2 business days" statement on Acro website was accurate. Fast shipment. Professional COA and instructions on how to reconstitute and store this product.
  • 1***02019-10-11
    Human CD38 Protein, His Tag, low endotoxin (Mass Spec & MALS verified)
    I bought a lot of products. This protein has high purity and good bioactivity. Whether it is for ELISA or functional assay, all went smoothly. The price is favorable and the service is also good. I support and recommend ACRO! Go ACRO!