CD300a Overview
Molecule Name
CMRF35-like molecule 8
Synonyms
CD300A,CLM-8,CMRF-35-H9,CMRF35-H9,CMRF35-H,IRC1,IRC2,IgSF12,IRp60,CMRF35H,IGSF12,LMIR1
Drug Development Progress
Drugs in Clinical Trials0
Approved Drugs0
Highest Development StagePreclinical
Target Synonym
CLM-8，CD300 antigen-like family member A，CMRF-35-H9 (CMRF35-H9)，CMRF35-H，IRC1/IRC2，Immunoglobulin superfamily member 12 (IgSF12)，Inhibitory receptor protein 60 (IRp60)，NK inhibitory receptor
Background
CD300a, expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes. Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6.
CD300a Product List
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