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CD133

CD133 Overview

English Name	CD133	Approved Drugs	0
Drugs in Clinical Trials	2	Target Synonym	Antigen AC133，Prominin-1，PROM1，Prominin 1，Prominin-Like Protein 1，PROML1，Stargardt Disease 4 (Autosomal Dominant)，Hematopoietic Stem Cell Antigen，Macular Dystrophy， Retinal 2，Prominin (Mouse)-Like 1，CD133 Antigen，HProminin，MSTP061，CORD12，AC133，CD133，MCDR2，STGD4，RP41，AC133 Antigen
Highest Development Stage	Phase 2 Clinical

English Name	CD133
Target Synonym	Antigen AC133，Prominin-1，PROM1，Prominin 1，Prominin-Like Protein 1，PROML1，Stargardt Disease 4 (Autosomal Dominant)，Hematopoietic Stem Cell Antigen，Macular Dystrophy， Retinal 2，Prominin (Mouse)-Like 1，CD133 Antigen，HProminin，MSTP061，CORD12，AC133，CD133，MCDR2，STGD4，RP41，AC133 Antigen
Approved Drugs	0
Drugs in Clinical Trials	2
Highest Development Stage	Phase 2 Clinical

CD133 Product List

Product Category
Protein (7)Cell (1)
Product Status
Launched (8)
Species
Human (7)Cynomolgus (1)
Tag
His Tag (3)- (3)His Tag & Avi Tag (1)His Tag & Flag Tag (1)
Conjugate
Unconjugated (4)Biotin-labeled (2)- (1)PE Labeled (1)

Cat. No.	Species	Host	Product Description
HOT CD3-H52H1	Human	HEK293	Human CD133 Full Length Protein, His Tag (Nanodisc)
HOT CD3-H52P3	Human	HEK293	Human CD133 Full Length Protein (VLP)
HOT CD3-C82E3	Cynomolgus	HEK293	Biotinylated Cynomolgus CD133 Full Length Protein, His,Avitag™ (Detergent)
CD3-H51D3	Human	E. coli	Human CD133 Full Length Protein, His,Flag Tag (Detergent)
CD3-H52H4	Human	HEK293	Human CD133 Protein, His Tag (Detergent)
CD3-H82D3	Human	HEK293	Biotinylated Human CD133 Full Length Protein, His,Flag Tag&Avitag™ (Detergent)
CD3-HP2H8	Human	HEK293	PE-Labeled Human CD133 Protein, His Tag
CHEK-ATP255	Human	HEK293	HEK293/Human CD133 Stable Cell Line

Total: 8

CD133 Background

Prominin-1 is also known as CD133, Antigen AC133, PROM1, PROML1 and MSTP061. Is used as marker for hematopoietic stem and progenitor cells (HSPC) for somatic stem cell isolation. May play a role in cell differentiation, proliferation and apoptosis . Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.

CD133 Synonyms

CD133,PROM1,PROML1,Prominin-1,AC133

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
P-134	P-134; P134	Phase 2 Clinical	Tianjin Tasly Pharmaceutical Co Ltd	Glioblastoma	Details
anti-CD133-CAR vector-transduced T cells		Phase 2 Clinical	Pla General Hospital	Brain Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Liver Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma	Details