CD109

CD109 Overview

English Name	DNA polymerase alpha subunit	Approved Drugs	2
Drugs in Clinical Trials	3	Target Synonym	P180，N Syndrome (Mental Retardation， Malformations， Chromosome Breakage)，NSX，VEODS，Polymerase (DNA Directed)， Alpha，POLA1，Polymerase (DNA-Directed)， Alpha (70kD)，DNA Polymerase Alpha 1， Catalytic Subunit，POLA，EC:2.7.7.7，EC 2.7.7.7，DNA Polymerase Alpha Catalytic Subunit，DNA Polymerase Alpha Catalytic Subunit P180，Polymerase (DNA) Alpha 1， Catalytic Subunit，DNA Polymerase I，Polymerase (DNA Directed)， Alpha 1， Catalytic Subunit
Highest Development Stage	Approved

English Name	DNA polymerase alpha subunit
Target Synonym	P180，N Syndrome (Mental Retardation， Malformations， Chromosome Breakage)，NSX，VEODS，Polymerase (DNA Directed)， Alpha，POLA1，Polymerase (DNA-Directed)， Alpha (70kD)，DNA Polymerase Alpha 1， Catalytic Subunit，POLA，EC:2.7.7.7，EC 2.7.7.7，DNA Polymerase Alpha Catalytic Subunit，DNA Polymerase Alpha Catalytic Subunit P180，Polymerase (DNA) Alpha 1， Catalytic Subunit，DNA Polymerase I，Polymerase (DNA Directed)， Alpha 1， Catalytic Subunit
Approved Drugs	2
Drugs in Clinical Trials	3
Highest Development Stage	Approved

CD109 Product List

Product Category
Protein (4)
Product Status
Launched (4)
Species
Human (3)Cynomolgus (1)
Tag
His Tag & Avi Tag (1)His Tag (2)Fc Tag (1)
Conjugate
Biotin-labeled (1)Unconjugated (3)

Cat. No.	Species	Host	Product Description	Order Now
CD9-H5256	Human	HEK293	Human CD109 / CPAMD7 protein, Fc Tag	Add to Cart
CD9-H52H3	Human	HEK293	Human CD109 / CPAMD7 Protein, His Tag	Add to Cart
CD9-H82E4	Human	HEK293	Biotinylated Human CD109 / CPAMD7 Protein, His,Avitag™ (MALS & SPR verified)	Add to Cart
CD9-C52H5	Cynomolgus	HEK293	Cynomolgus CD109 / CPAMD7 Protein, His Tag	Add to Cart

Total: 4

CD109 Background

CD109 is a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. CD109 is expressed in many malignant tumors, including various squamous cell carcinomas and adenocarcinomas, and plays a role as a multifunctional coreceptor.CD109 reportedly associates with transforming growth factor (TGF)-β receptors and negatively regulates TGF-β signaling in keratinocytes. Additionally, CD109 is potentially related to signal transducer and activator of transcription-3 signaling and aberrant cell proliferation.

CD109 Synonyms

CD109,CPAMD7,r150,p180,CPAMD7

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Clofarabine (Boyen)	BY-101	Phase 3 Clinical	Boyen Therapeutics Inc	Leukemia, Myeloid, Acute	Details
Alkasar-18	NOAC; Alkasar-18; N4-octadecyl-ara-C	Phase 1 Clinical	University of Zurich	Cerebral Hemorrhage; Neoplasms; Atrial Fibrillation	Details
Sapacitabine	CS-682; CYC-682	Phase 1 Clinical	Daiichi Sankyo Co Ltd	Leukemia; Myelodysplastic Syndromes; Breast Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, T-Cell, Cutaneous; Carcinoma, Non-Small-Cell Lung	Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Clofarabine	CAFdA; JC0707; GZ-393590; SAR-393590; 2-Cl-2-F-araA	Approved	Genzyme Corp	Clolar, Evoltra, Ivozall, Clofarex	United States	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Genzyme Corp	2004-12-28	Neoplasms; Angioimmunoblastic T-cell Lymphoma; Leukemia, Lymphocytic, Chronic, B-Cell; Waldenstrom Macroglobulinemia; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute; Lymphoma; Lymphoproliferative Disorders; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Histiocytosis, Langerhans-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Multiple Myeloma; Leukemia; Lymphoma, Large B-Cell, Diffuse; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Leukemia, Lymphoid; Intestinal Neoplasms; Lymphoma, T-Cell, Peripheral; Lymphoma, B-Cell, Marginal Zone; Lymphoma, B-Cell; Hematologic Neoplasms; Leukemia, Myeloid; Leukemia, Myelogenous, Chronic; Solid tumours	Details
Nelarabine	506U; 506-U78; GW-506U; GW-506U78; GI-262250X; NSC-686673	Approved	Novartis Pharma Ag, Glaxosmithkline Plc	Arranon, ArranonG, Atriance	United States	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Sandoz	2005-10-28	Sezary Syndrome; Mycosis Fungoides; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, T-Cell; Angioimmunoblastic T-cell Lymphoma; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell, Cutaneous; Waldenstrom Macroglobulinemia; Lymphoma, T-Cell; Lymphoma, Non-Hodgkin; Lymphoma; Leukemia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Follicular; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Multiple Myeloma; Leukemia-Lymphoma, Adult T-Cell; Myeloproliferative Disorders; Myelodysplastic Syndromes; Plasmacytoma; Lymphoma, B-Cell, Marginal Zone	Details