4-1BB Ligand

4-1BB Ligand Overview

English Name	Tumor necrosis factor ligand superfamily member 9	Approved Drugs	0
Drugs in Clinical Trials	2	Target Synonym	4-1BB ligand，4-1BBL
Highest Development Stage	Phase 2 Clinical

English Name	Tumor necrosis factor ligand superfamily member 9
Target Synonym	4-1BB ligand，4-1BBL
Approved Drugs	0
Drugs in Clinical Trials	2
Highest Development Stage	Phase 2 Clinical

4-1BB Ligand Product List

Product Category
Protein (9)Cell (1)Cell Grade Beads (1)Kits (1)
Product Status
Launched (12)
Species
Mouse (1)Human (9)Rat (1)Cynomolgus (1)
Tag
Fc Tag (5)Fc Tag & Avi Tag (1)His Tag & Flag Tag (2)- (3)Avi Tag & Fc Tag (1)
Conjugate
Unconjugated (7)Biotin-labeled (2)- (3)

Cat. No.	Species	Host	Product Description	Order Now
HOT 41L-H5269	Human	HEK293	Human 4-1BB Ligand / TNFSF9 (71-254) Protein, Fc Tag, active trimer, premium grade	Add to Cart
HOT 41L-H52D4	Human	HEK293	Human 4-1BB Ligand / TNFSF9 (71-254) Protein, His,Flag Tag, active trimer, low endotoxin (MALS verified)	Add to Cart
HOT 41L-H82F9	Human	HEK293	Biotinylated Human 4-1BB Ligand / TNFSF9 Protein, Fc,Avitag™, premium grade	Add to Cart
HOT GMP-41LH26	Human	HEK293	GMP Human 4-1BB Ligand Protein, Fc Tag	Add to Cart
41L-H5266	Human	HEK293	Human 4-1BB Ligand / TNFSF9 (71-254) Protein, Fc Tag, active trimer, Research Grade	Add to Cart
41L-H82Fa	Human	HEK293	Biotinylated Human 4-1BB Ligand / TNFSF9 (71-254) Protein, Fc,Avitag™, premium grade	Add to Cart
CHEK-ATP039	Human	HEK293	HEK293/Human 4-1BB Ligand / TNFSF9 Stable Cell Line	Add to Cart
MBS-C012	Human	-	ActiveMax® Human 4-1BB Ligand / TNFSF9 (71-254) μBeads, premium grade (for cells)	Add to Cart
RES-A036	Human	-	resDetect™ Human 4-1BB Ligand ELISA Kit (Residue Testing)	Add to Cart
41L-M5257	Mouse	HEK293	Mouse 4-1BB Ligand / TNFSF9 Protein, Fc Tag	Add to Cart

Total: 12

4-1BB Ligand Background

Tumor necrosis factor ligand superfamily member 9 (4-1BBL) is also known as 4-1BB ligand, CD137L or TNFSF9, which is a cytokine that binds to TNFRSF9. 4-1BBL is the high affinity ligand of 4-1BB. 4-1BBL induces the proliferation of activated peripheral blood T-cells. Also, 4-1BBL may have a role in activation-induced cell death (AICD). Furthermore, 4-1BBL may play a role in cognate interactions between T-cells and B-cells/macrophages. As for diseases, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.

4-1BB Ligand Synonyms

4-1BB Ligand,TNFSF9,CD137L

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
RTX-224	RTX-224	Phase 2 Clinical	Rubius Therapeutics Inc	Carcinoma, Non-Small-Cell Lung; Carcinoma, Transitional Cell; Skin Melanoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms	Details
RP-3	RP-3	Phase 2 Clinical	Replimune Inc	Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Colorectal Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck	Details

Product Reviews

P***l2025-05-30
3People Like
GMP Human 4-1BB Ligand Protein, Fc Tag
Hi, I work for a start-up company, Nkure Therapeutics, in Bangalore. We have used GMP-4-1BBL from AcroBio and it worked well in our hands for a therapeutic dose. We culture primary cells as such NK cells to provide a cell therapy against cancer. We are happy with the service and the product quality as well. We compared the data of NK cell expansion with Croyez 4-1-BBL and AcroBio 4-1-BBL and realized there is no difference in the potency, however there is a huge difference in the price. AcroBio provides smaller pack size with a good price range as well.
a***n2025-02-06
3People Like
GMP Human 4-1BB Ligand Protein, Fc Tag
Your FACS antibodies of great. worked greatly to study immune cell and activation markers study with extradentary available conjugates for Flow cytometry