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Human ULBP1 Protein, His Tag (MALS verified)

AIDD‑Ready
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UL1-H52H3-100ug
$360.00
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UL1-H52H3-1mg (500ug X 2)
$2,615.00
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UL1-H52H3
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Product Details
Performance Data
Reviews & Citations
Resources
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
Synonyms

N2DL-1, NKG2DL1, RAET1I

Source

Human ULBP1 Protein, His Tag (UL1-H52H3) is expressed from human 293 cells (HEK293). It contains AA Gly 26 - Pro 215 (Accession # Q9BZM6).

Predicted N-terminus: Gly 26

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 24.2 kDa. The protein migrates as 28-35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Purity

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Background

ULBP1 is UL16 binding protein 1, also known as NKG2DL1, RAET1I, ALCAN-beta. It is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T cells. Binding of ULBP1 to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. In cytomegalovirus-infected cells, ULBP1 binds the UL16 glycoprotein and is prevented from activating the immune system.