Human NPTX2 Protein, His Tag (MALS verified)

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Cat. No. / Size
Price
Qty
NP2-H52H6-100ug
$360.00
NP2-H52H6-1mg (500ug X 2)
$2380.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    Neuronal pentraxin II, NP-II

  • Source

    Human NPTX2, His Tag (NP2-H52H6) is expressed from human 293 cells (HEK293). It contains AA Gly 16 - Leu 431 (Accession # P47972).

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  • Molecular Characterization

    NPTX2 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 47.7 kDa. The protein migrates as 50-63 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    NPTX2 SDS-PAGE

    Human NPTX2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    NPTX2 SEC-MALS

    The purity of Human NPTX2, His Tag (Cat. No. NP2-H52H6) is more than 85% and the molecular weight of this protein is around 315-335 kDa verified by SEC-MALS.

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Background

Neuronal Pentraxin 2 (NPTX2), also named neuronal activity-regulated pentraxin, is a secreted glycoprotein characterized by a cyclic multimeric structure. In vivo, NTPX2 exerts various neurological effects by combining with the transmembrane protein neuronal pen traxin receptor (NPTXR). NPTX2 was thought to play a vital role in transmitting neurotrans mitters and maintaining synaptic plasticity. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD.

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