Human LRP-1 / cluster Ⅳ Protein, Fc Tag

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Cat. No. / Size
Price
Qty
LR1-H5256-100ug
$410.00
LR1-H5256-1mg (200ug X 5)
$2885.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    A2MR, APOER, APR, CD91, IGFBP-3R, IGFBP3R, IGFBP3R1, KPA, LRP, LRP1A, TGFBR5

  • Source

    Human cluster Ⅳ Protein, Fc Tag (LR1-H5256) is expressed from human 293 cells (HEK293). It contains AA Ser 3332 - Asp 3779 (Accession # Q07954-1).

    Predicted N-terminus: Ser 3332

    Request for sequence
  • Molecular Characterization

    LRP-1 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 76.6 kDa. The protein migrates as 95-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    LRP-1 SDS-PAGE

    Human cluster Ⅳ Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • Bioactivity-BLI

     LRP-1 BLI

    Loaded Unconjugated Human PDGF-BB, His,Avitag (Cat. No. PDB-H5127) on NTA Biosensor, can bind Human cluster Ⅳ Protein, Fc Tag (Cat. No. LR1-H5256) with an affinity constant of 4.82nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

    Protocol

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Background

Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is a protein forming a receptor found in the plasma membrane of cells. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor. LRP1 is also a key signalling protein and, thus, involved in various biological processes, such as lipoprotein metabolism and cell motility, and diseases, such as neurodegenerative diseases, atherosclerosis, and cancer.

Recent Advances

 
Drug Development Progress
  • English Name:

    Low density lipoprotein receptor-related protein-1

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

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  • Highest Development Stage:

    Preclinical

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