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Human IRAK4 Protein, His Tag (active enzyme)

AIDD‑Ready
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IR4-H5543-100ug
$399.00
In Stock - Delivery in 2-3 weeks
IR4-H5543-1mg
$2,940.00
In Stock - Delivery in 2-3 weeks
IR4-H5543
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Synonyms

IMD67, IPD1, IRAK-4, NY-REN-64, REN64

Source

Human IRAK4 Protein, His Tag (IR4-H5543) is expressed from Baculovirus-Insect cells. It contains AA Glu 154 - Ser 460 (Accession # Q9NWZ3-1).

Predicted N-terminus: Met

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 36.4 kDa. The protein migrates as 38-40 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Purity

>90% as determined by SDS-PAGE.

Formulation

Supplied as 0.2 μm filtered solution in 50 mM HEPES, 300 mM NaCl, pH7.5 with glycerol as protectant.

Contact us for customized product form or formulation.

Shipping and Storage

This product is supplied and shipped on dry ice.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • The product MUST be stored at -70°C or lower upon receipt;
  • -70°C for 3 months under sterile conditions.
ACRO Quality Management System

Background

This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.