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Human CCR6 Full Length Protein, Flag,His Tag (Detergent)

AIDD‑Ready
Cat. No. / Size
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CC6-H51D3-20ug
$496.00
In Stock - Delivery in 1-2 business days
CC6-H51D3-100ug
$988.00
In Stock - Delivery in 2-3 weeks
CC6-H51D3-500ug
$4,305.00
In Stock - Delivery in 2-3 weeks
CC6-H51D3
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Product Details
Performance Data
Reviews & Citations
Resources
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
Application
  • Immunization
  • Affinity testing (SPR / BLI)
  • Screening (ELISA)
Synonyms

BN-1, C-C CKR-6, CC-CKR-6, CCR-6, CD196, CKR-L3, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22

Source

Detergent Human CCR6 Full Length Protein, Flag,His Tag (CC6-H51D3) is expressed from E. coli system. It contains AA Ser 2 - Met 374 (Accession # P51684).

Predicted N-terminus: Met

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries a polyhistidine tag at the N-terminus and a Flag tag at the C-terminus.

The protein has a calculated MW of 48.1 kDa. The protein migrates as 41-42 kDa, 65-75 kDa and 95-110 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

*The detergent Buffer B (Cat. No. LG-13) is sold separately and not included in protein, you can follow the link for product information.

Structure

Each full-length transmembrane protein is encapsulated by detergent micelle.

Synthesis Process

Through mild detergent micelle extraction, dedicated solubilization, and stringent affinity purification, we maximally retain the native transmembrane conformation of full-length transmembrane proteins throughout downstream purification. This workflow yields purified, detergent-solubilized proteins free of unrelated membrane impurities and exogenous scaffold proteins, with exceptional purity, accurate quantitation, and well-preserved biological activity—ideal for immunization, binding assays in antibody discovery and screening (ELISA) and affinity testing (SPR and BLI), etc.

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Purity

>90% as determined by SDS-PAGE.

Formulation

This product is not suitable for cell based experiments due to cytotoxicity of detergent.
Detergent buffer is INDISPENSABLE to keep membrane protein soluble and active, under no circumstances should you remove detergent.
Detergent buffer is sold separately and not included in protein, and please contact us if you need the buffer.
If glycerol is not compatible with your application, remove glycerol just before the immediate experiment, and NEVER store glycerol-free protein solution.

Supplied as 0.2 μm filtered solution in 50 mM HEPES, 150 mM NaCl, Buffer B, CHS, pH7.5 with glycerol as protectant.

Contact us for customized product form or formulation.

Shipping and Storage

This product is supplied and shipped on dry ice.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • The product MUST be stored at -70°C or lower upon receipt;
  • -70°C for 6 months under sterile conditions.
ACRO Quality Management System

Background

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.