Human APP / Abeta40 (672-711) Protein, His Tag

Customer Reviews
Cat. No. / Size
Price
Qty
APP-H51H9-100ug
$380.00
APP-H51H9-500ug
$1150.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    ABPP, APPI, Amyloid-beta A4 protein

  • Source

    Human Abeta40 (672-711) Protein, His Tag (APP-H51H9) is expressed from E. coli cells. It contains AA Asp 672 - Val 711 (Accession # P05067-1).

    Predicted N-terminus: Met

    Request for sequence
  • Molecular Characterization

    APP Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 6.3 kDa. The protein migrates as 9-10 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 20 mM NaOH with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

Customers Also Viewed

Performance Data

  • SDS-PAGE

    APP SDS-PAGE

    Human Abeta40 (672-711) Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • Bioactivity-ELISA

     APP ELISA

    Immobilized Human Abeta40 (672-711) Protein, His Tag (Cat. No. APP-H51H9) at 5 μg/mL (100 μL/well) can bind Biosimilar Aducanumab with a linear range of 0.06-2 ng/mL (QC tested).

    Protocol

Customer Reviews
Writing Reviews

Background

Amyloid precursor protein (APP) is a type I integral membrane protein ubiquitously expressed in many tissues and concentrated in the synapses of neurons. It has three predominant splice variants: APP695, APP751, and APP770. The majority of APP is cleaved at the plasma membrane by the α-secretase in the non-amyloidogenic pathway. The amyloidogenic pathway starts with β-secretase cleavage by BACE1 on the N-terminal part of the Aβ domain, releasing sAPPβ from a membrane-anchored fragment named βCTF or C99, which is subsequently cleaved by γ-secretase to release Aβ.

Recent Advances

 
Drug Development Progress
  • English Name:

    Beta amyloid A4 protein

  • Category:

  • Approved Drugs:

    13 Details

  • Drugs in Clinical Trials:

    54 Details

  • Highest Development Stage:

    Approved

Drug Candidate Licensing
More
  • Basic Product Information
  • Product Details
  • Customers Also Viewed
  • Performance Data
  • Customer Reviews
  • Background