Human Activin A / INHBA Superior Active Mutant Protein, premium grade

Features and Advantages

1. Engineered via a Closed-Loop AI Design Platform – Enables rational sequence optimization to achieve maximal functional performance.
2. Superior Bioactivity (2× Higher than WT Activin A) – Delivers stronger signaling for more potent and rapid differentiation initiation.
3. Enables Efficient & Consistent Endoderm Differentiation – Reduces reagent usage, lowers overall costs, and accelerates the generation of functional lineages such as pancreatic beta islet cells.

Synonyms

Activin A, INHBA

Product Details

Our Recombinant Human Activin A Superior Active Mutant Protein, developed via an AI-modified and experimentally validated closed-loop efficient protein design platform, is the optimal Activin A mutant with superior bioactivity (2 times higher) compared to wild-type Activin A. It highly facilitates stem cell differentiation into definitive endoderm lineages, including pancreatic beta islet cells and other related cell types. This enables more efficient and stable differentiation outcomes with reduced reagent consumption, significantly lowering costs while enhancing process reliability. The product provides strong support for optimizing islet differentiation and downstream cell therapy applications, offering a powerful solution for scalable and cost-effective stem cell-based production.

It is produced under our rigorous quality control system that incorporates a comprehensive set of tests including sterility and endotoxin tests. Product performance is carefully validated and tested for compatibility for cell culture use or any other applications in the early preclinical stage. When ready to transition into later clinical phases, we also offer a custom GMP protein service that tailors to your needs. We will work with you to customize and develop a GMP-grade product in accordance with your requests that also meets the requirements for raw and ancillary materials use in cell manufacturing of cell-based therapies.

Molecular Characterization

This protein carries no "tag".

The protein has a calculated MW of 13.0 kDa. The protein migrates as 14 kDa±3 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

Endotoxin

Less than 0.01 EU per μg by the LAL method / rFC method.

Host Cell Protein

<0.5 ng/µg of protein tested by ELISA.

Host Cell DNA

<0.02 ng/μg of protein tested by qPCR.

Sterility

Negative

Mycoplasma

Negative

Purity

>95% as determined by SDS-PAGE.

>95% as determined by SEC-HPLC.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Storage

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.

ACRO Quality Management System

1. QMS(ISO, GMP)
2. Quality Advantages
3. Quality Control Process