Monoclonal Anti-Her2 Antibody, Human IgG1

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Cat. No. / Size
Price
Qty
HE2-M598-100ug
$230.00
HE2-M598-1mg
$1380.00
ETA of in-stock products:2 business days

Product Details

  • Source

    Monoclonal Anti-Her2 Antibody, Human IgG1 is a recombinant chimeric monoclonal antibody expressed in HEK293, which combines the variable region of a mouse monoclonal antibody with human constant domain.

  • Antibody Type

    Recombinant Monoclonal

  • Isotype

    Human IgG1, Kappa

  • Host Species

    Mouse

  • Reactivity

    Human

  • Specificity

    This product is a specific antibody against Her2.

  • Application

    Application
    Recommended Usage
    ELISA
    0.2-2 μg/mL
  • Purification

    Protein A purified / Protein G purified.

  • Concentration

    Please refer to the Certificate of Analysis (CoA).

  • Form

    Liquid

  • Formulation

    Supplied a 0.22 μm-filtered solution in pH 6.0, 20 mM L-Histidine, with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 12 months under sterile conditions.
  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Bioactivity-ELISA

     Her2 ELISA

    Immobilized Human Her2, His Tag (Cat. No. HE2-H5225) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Her2 Antibody, Human IgG1 (Cat. No. HE2-M598) with a linear range of 0.06-2 ng/mL (QC tested).

    Protocol
  •  Her2 ELISA

    Immobilized Human Her2 (498-648), His Tag (Cat. No. HE2-H52H4) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Her2 Antibody, Human IgG1 (Cat. No. HE2-M598) with a linear range of 0.06-2 ng/mL (Routinely tested).

    Protocol
  •  Her2 ELISA

    Immobilized Human Her2 (S310F), His Tag (Cat. No. HE2-H52H2) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Her2 Antibody, Human IgG1 (Cat. No. HE2-M598) with a linear range of 0.06-2 ng/mL (Routinely tested).

    Protocol
  •  Her2 ELISA

    Immobilized Human Her2 (S310Y), His Tag (Cat. No. HE2-H52H3) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Her2 Antibody, Human IgG1 (Cat. No. HE2-M598) with a linear range of 0.06-2 ng/mL (Routinely tested).

    Protocol

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Background

Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2 /neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation .

Recent Advances

 
Drug Development Progress
  • English Name:

    Receptor protein-tyrosine kinase erbB-2

  • Category:

  • Approved Drugs:

    47 Details

  • Drugs in Clinical Trials:

    238 Details

  • Highest Development Stage:

    Approved

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