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Product Details
Source
Monoclonal Anti-DM-4 Antibody, Rabbit IgG (M1H02) is a rabbit monoclonal antibody recombinantly expressed in HEK293 cells.
Antibody Type
Recombinant Monoclonal
Clone
M1H02
Isotype
Rabbit IgG, Kappa
Host Species
Rabbit
Immunogen
DM-4-BSA
Specificity
Specifically recognizes the target DM-1 & DM-4.
Purification
Protein A purified / Protein G purified.
Concentration
Please refer to the Certificate of Analysis (CoA).
Form
Lyophilized
Formulation
Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.
Please contact us for customized product forms or formulations.
Reconstitution
Please refer to the Certificate of Analysis (CoA) for specific instructions.
Shipping
Lyophilized product is shipped at ambient temperature.
Storage
For long term storage, the product should be stored in a lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
Notices
Product Specific Notices: For research use only.
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Performance Data
Bioactivity-ELISA
Immobilized Monoclonal Anti-DM-4 Antibody, Rabbit IgG (M1H02) (Cat. No. DM4-MY2519a) at 1 μg/mL, add Tusamitamab Ravtansine in the 100% Human Serum and then add Biotinylated Human CEACAM-5, His,Avitag at 0.5 μg/mL. Detection was performed using HRP-conjugated Streptavidin (Acro, Cat. No. STN-NH913) (QC tested).
Protocol
Serial dilutions of DM4 were added into Monoclonal Anti-DM-4 Antibody, Rabbit IgG (M1H02) (Cat. No. DM4-MY2519a): Tusamitamab Ravtansine binding reactions. The half maximal inhibitory concentration (IC50) is 0.06 μg/mL (Routinely tested).
Protocol
Immobilized Monoclonal Anti-DM-4 Antibody, Rabbit IgG (M1H02) (Cat. No. DM4-MY2519a) at 1 μg/mL (100 μL/well) can bind Tusamitamab Ravtansine with a linear range of 0.5-16 ng/mL (Routinely tested).
Protocol
Cross Verification
ELISA binding of Monoclonal Anti-DM-4 Antibody, Rabbit IgG (M1H02) (Cat. No. DM4-MY2519a) with Tusamitamab Ravtansine, Trastuzumab Deruxtecan, Sacituzumab Govitecam, Disitamab Vedotin (RC48), ADC-Duocarmycin and Trastuzumab MMAE conjugated antibody respectively.
The coating antibody was Monoclonal Anti-DM-4 Antibody, Rabbit IgG (M1H02) (Cat. No. DM4-MY2519a), used at 1 μg/mL concentration. The primary antibody were different payload conjugated antibodies, including Tusamitamab Ravtansine, Trastuzumab Deruxtecan, Sacituzumab Govitecam, Disitamab Vedotin (RC48), ADC-Duocarmycin and Trastuzumab MMAE conjugated antibodies used at 0.5 μg/mL concentration. The secondary antibody was HRP conjugated Anti-Human-IgG-Fc Antibody (6F11C8), mAb (Acro, Cat. No. IGG-LY69) used at 1:10000 concentration.
Monoclonal Anti-DM-4 Antibody, Rabbit IgG (M1H02) (Cat. No. DM4-MY2519a) is specific to Tusamitamab Ravtansine, and has no cross-reactivity with Trastuzumab Deruxtecan, Sacituzumab Govitecam, Disitamab Vedotin (RC48), ADC-Duocarmycin and Trastuzumab MMAE (Routinely tested).
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