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Home PageAll MoleculesLaminin 121 E8
Laminin 121 E8
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Laminin 121 E8 Background
Laminin-121 is one of the α1 chain containing laminins. The α1 chain is detected at the 2-cell stage of the pre-implantation mouse embryo and is subsequently expressed mainly in many epithelial tissues during organogenesis. Laminin-121 showed the highest affinity to α6β1 and α7β1 integrins and furthermore, laminin-121 most effectively supported neurite outgrowth.
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Atacicept | TACI-Ig | Phase 3 Clinical | Zymogenetics Inc | Glomerulonephritis, IGA; Kidney Diseases; Arthritis, Rheumatoid; Multiple Sclerosis; Optic Neuritis; Lupus Nephritis; Urinary Bladder Diseases; Lupus Erythematosus, Systemic | Details |
| Povetacicept | ALPN-303; ALPN 30x | Phase 3 Clinical | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Purpura, Thrombocytopenic, Idiopathic; Myasthenia Gravis; Glomerulonephritis, IGA; Sjogren's Syndrome; Glomerulonephritis, Membranous; Lupus Nephritis; Lupus Erythematosus, Systemic; Anemia, Hemolytic, Autoimmune; Inflammation; Cytopenia; Glomerulonephritis | Details | |
| Rozibafusp alfa | AMG-570; MEDI-0700 | Phase 2 Clinical | Amgen Inc | Arthritis, Rheumatoid; Lupus Erythematosus, Systemic | Details |
| Tabalumab | LY-2127399 | Phase 2 Clinical | Eli Lilly And Company | Multiple Sclerosis, Relapsing-Remitting; Dermatomyositis; Arthritis, Rheumatoid; Autoimmune Diseases; Scleroderma, Systemic; Multiple Myeloma; Connective Tissue Diseases; Arthritis, Juvenile; Multiple Sclerosis; Lupus Erythematosus, Systemic; Kidney Failure, Chronic; Pemphigus | Details |
| UBP-1213 | UBP-1213 | Phase 1 Clinical | Wuhan Huaxin Kangyuan Biomedicine Co Ltd, Shanghai Junshi Biosciences Co Ltd | Lupus Erythematosus, Systemic | Details |
| Autologous CAR-T cell therapy expressing the BAFF-ligand | LMY-920; LUMT1A22 | Phase 1 Clinical | Luminary Therapeutics Inc | Sjogren's Syndrome; Scleroderma, Systemic; Multiple Myeloma; Lupus Erythematosus, Systemic; Lymphoma, Mantle-Cell | Details |
| UBP1213sc | UBP1213sc | Phase 1 Clinical | Lupus Nephritis; Lupus Erythematosus, Systemic | Details |
Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | Earliest Brand Name | Earliest Approval Country | Earliest Indication | Earliest Approval Company | Earliest Approval Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Telitacicept | RCT-18; RC-18; RCT18; RC18 | Approved | RemeGen Co Ltd | Mainland China | Lupus Erythematosus, Systemic | RemeGen Co Ltd | 2021-03-09 | Myasthenia Gravis; Multiple Sclerosis, Relapsing-Remitting; Glomerulonephritis, IGA; Nephrosis; Immunoglobulin G4-Related Disease; Arthritis, Rheumatoid; Sjogren's Syndrome; Multiple Sclerosis; Lupus Nephritis; Neuromyelitis Optica; Lupus Erythematosus, Systemic | Details | |
| Belimumab | BmAb; GSK-1550188; HGS-1006 | Approved | Glaxosmithkline Plc | Benlysta, 倍力腾 | United States | Lupus Erythematosus, Systemic | Human Genome Sciences Inc | 2011-03-09 | Antiphospholipid Syndrome; Leukemia, Lymphocytic, Chronic, B-Cell; Bronchial Diseases; Emphysema; Pulmonary Disease, Chronic Obstructive; Waldenstrom Macroglobulinemia; Hepatitis, Autoimmune; Lymphopenia; Rheumatic Diseases; Sjogren-Larsson Syndrome; Lupus Erythematosus, Systemic; systemic sclerosis-associated interstitial lung disease; Mixed Connective Tissue Disease; Myasthenia Gravis; Glomerulonephritis, Membranous; Lung Diseases, Interstitial; Lupus Nephritis; Graft vs Host Disease; Purpura; Arthritis, Rheumatoid; Scleroderma, Systemic; Myositis; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Granulomatosis with Polyangiitis; Rejection of renal transplantation | Details |
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