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DR3 / TNFRSF25

DR3 / TNFRSF25 Overview

English Name	Tumor necrosis factor receptor superfamily member 25	Approved Drugs	0
Drugs in Clinical Trials	0	Target Synonym	Apo-3，Apoptosis-inducing receptor AIR，Apoptosis-mediating receptor DR3，Apoptosis-mediating receptor TRAMP，Death receptor 3，Lymphocyte-associated receptor of death，Protein WSL，DDR3，Death Receptor Beta，TNFRSF12，TRAMP，DR3，WSL-1，PH Domain-Containing Family G Member 5，PLEKHG5，WSL-LR，WSL1，APO3，WSL，TR3，TNF Receptor Superfamily Member 25，Death Domain Receptor 3 Soluble Form，GEF720，Guanine Nucleotide Exchange Factor 720，Apoptosis Inducing Receptor，Tumor Necrosis Factor Receptor Superfamily， Member 25，Pleckstrin Homology Domain-Containing Family G Member 5，Protein WSL-1，LARD，Tumor Necrosis Factor Receptor Superfamily， Member 12 (Translocating Chain-Association Membrane Protein)
Highest Development Stage	Preclinical

English Name	Tumor necrosis factor receptor superfamily member 25
Target Synonym	Apo-3，Apoptosis-inducing receptor AIR，Apoptosis-mediating receptor DR3，Apoptosis-mediating receptor TRAMP，Death receptor 3，Lymphocyte-associated receptor of death，Protein WSL，DDR3，Death Receptor Beta，TNFRSF12，TRAMP，DR3，WSL-1，PH Domain-Containing Family G Member 5，PLEKHG5，WSL-LR，WSL1，APO3，WSL，TR3，TNF Receptor Superfamily Member 25，Death Domain Receptor 3 Soluble Form，GEF720，Guanine Nucleotide Exchange Factor 720，Apoptosis Inducing Receptor，Tumor Necrosis Factor Receptor Superfamily， Member 25，Pleckstrin Homology Domain-Containing Family G Member 5，Protein WSL-1，LARD，Tumor Necrosis Factor Receptor Superfamily， Member 12 (Translocating Chain-Association Membrane Protein)
Approved Drugs	0
Drugs in Clinical Trials	0
Highest Development Stage	Preclinical

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DR3 / TNFRSF25 Background

Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) is also known as Apo-3, Death receptor 3 (DDR3 or DR3), Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor TRAMP, Lymphocyte-associated receptor of death, Apo-3, which is a member of the TNF-receptor superfamily. TNFRSF25 is a homodimer protein, which can Interact strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. TNFRSF25 is receptor for TNFSF12 / APO3L / TWEAK.