ASGR1&ASGR2 Product List
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Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Romiplostim biosimilar (Enzene Biosciences) | 267639-76-9 | Phase 3 Clinical | Enzene Biosciences Ltd | Purpura, Thrombocytopenic, Idiopathic | Details |
| Romiplostim biosimilar (Intas Pharmaceuticals) | Phase 3 Clinical | Intas Biopharmaceuticals | Purpura, Thrombocytopenic, Idiopathic | Details | |
| Romiplostim biosimilar(Generium) | GNR-069 | Phase 3 Clinical | Cjsc Generium | Purpura, Thrombocytopenic, Idiopathic | Details |
| Recombinant human thrombopoietin（Peking University People's Hospital） | Phase 2 Clinical | Peking University People'S Hospital | Purpura, Thrombocytopenic, Idiopathic | Details | |
| Recombinant human thrombopoietin mimetics (Shandong Quangang) | Phase 2 Clinical | Shandong Quangang Pharmaceutical Co Ltd | Purpura, Thrombocytopenic, Idiopathic | Details | |
| Recombinant human thrombopoietin (CPGJ) | Phase 1 Clinical | Sunshine GuoJian Pharmaceutical (Shanghai) Co Ltd | Thrombocytopenia | Details | |
| Pegylated thrombopoietin mimetic peptide | SF-303; JNJ-26366821; RWJ-800088; PEG-TPOm | Phase 1 Clinical | Johnson & Johnson | Details | |
| Romiplostim biosimilar(Geropharma) | GP-40141 | Phase 1 Clinical | Geropharm | Purpura, Thrombocytopenic, Idiopathic | Details |
| SCB-219 | SCB-219-M; SCB-219; SCB-219M | Phase 1 Clinical | Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia | Details | |
| Recombinant human thrombopoietin mimetic peptide-Fc fusion protein (Beijing Tide Pharmaceutical) | Phase 1 Clinical | Beijing Tide Pharmaceutical Co Ltd | Thrombocytopenia | Details | |
| PEGylated thrombopoietin (Chongqing Paijin Bio) | Phase 1 Clinical | Thrombocytopenia | Details | ||
| Thrombopoietin agonist (Scripps Research) | 3D9 | Clinical | The Scripps Research Institute Inc | Thrombocytopenia | Details |
Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | Earliest Brand Name | Earliest Approval Country | Earliest Indication | Earliest Approval Company | Earliest Approval Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Recombinant human thrombopoietin biosimilar (Biolotus) | Approved | Biolotus | Zypotin-TPO | Brazil | Thrombocytopenia | Biolotus | 2015-01-01 | Thrombocytopenia | Details | |
| Romiplostim | AMP-2; AMG-531 | Approved | Amgen Inc | Romiplate, Nplate | United States | Thrombocytopenia; Purpura, Thrombocytopenic, Idiopathic | Amgen Inc | 2008-08-22 | Bone Marrow Failure Disorders; Carcinoma, Non-Small-Cell Lung; Lymphoma; Lung Neoplasms; Lymphoma, Non-Hodgkin; Purpura, Thrombocytopenic; Thrombocytopenia; Acute Radiation Syndrome; Pancytopenia; Anemia, Aplastic; Solid tumours; Multiple Myeloma; Myelodysplastic Syndromes; Hodgkin Disease; Small Cell Lung Carcinoma; Neoplasms; Hematologic Neoplasms; Ovarian Neoplasms; Purpura, Thrombocytopenic, Idiopathic | Details |
| Lusutrombopag | S-888711 | Approved | Shionogi & Co Ltd | Mulpleta | Japan | Thrombocytopenia | Shionogi & Co Ltd | 2015-09-28 | Purpura, Thrombocytopenic, Idiopathic; Liver Diseases; Thrombocytopenia | Details |
| Herombopag Olamine | SHR-8735; SHR 8735 olamine | Approved | Hengqu, 恒曲 | Mainland China | Anemia, Aplastic; Thrombocytopenia | Jiangsu Hengrui Medicine Co Ltd | 2021-06-16 | Purpura, Thrombocytopenic, Idiopathic; Liver Diseases; Anemia, Aplastic; Breast Neoplasms; Thrombocytopenia; Carcinoma, Non-Small-Cell Lung | Details | |
| Recombinant human thrombopoietin mimetic-fusion protein (Qilu Pharmaceutical) | QL-0911 | Approved | Qilu Pharmaceutical Co Ltd | Mainland China | Thrombocytopenia | Qilu Pharmaceutical Co Ltd | 2024-04-02 | Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia | Details | |
| Eltrombopag Diolamine | SB-497115; SB-497115-GR; ETB-115 | Approved | Glaxosmithkline Plc | Revolade, Promacta/Revolade, 瑞弗兰, レボレード, Promacta | United States | Purpura, Thrombocytopenic, Idiopathic | Novartis Pharma Ag | 2008-11-20 | Osteosarcoma; Delayed Graft Function; Bone Marrow Failure Disorders; Liver Diseases; Leukemia, Megakaryoblastic, Acute; Multiple Myeloma; Hemorrhage; Anemia, Aplastic; Hepatitis B; Leukemia, Basophilic, Acute; Sarcoma; Liver Cirrhosis; Hepatitis C; Primary Myelofibrosis; Leukemia, Myeloid, Chronic-Phase; Thrombocytopenia; Leukemia, Myeloid, Acute; Leukemia, Monocytic, Acute; Hepatitis C, Chronic; Leukemia, Lymphocytic, Chronic, B-Cell; Catheter-Related Infections; Leukemia, Eosinophilic, Acute; Wiskott-Aldrich Syndrome; Leukemia; Solid tumours; Hematologic Neoplasms; HIV Infections; Leukemia, Myelogenous, Chronic; Bone marrow transplant rejection; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Accelerated Phase; Hematopoietic stem cell transplantation (HSCT); Purpura, Thrombocytopenic, Idiopathic; Metabolic Dysfunction-Associated Steatotic Liver Disease; Purpura; Myelodysplastic Syndromes; Blood Platelet Disorders; Anemia, Diamond-Blackfan; Fanconi Anemia; Leukemia, Myelomonocytic, Acu | Details |
| Avatrombopag Maleate | YM-477; AKR-501; AS-1670542; AKR-501-monomaleate; E-5501 | Approved | Astellas Pharma Inc | Doptelet, 苏可欣 | United States | Liver Diseases; Thrombocytopenia | Akarx Inc | 2018-05-21 | Drug-Related Side Effects and Adverse Reactions; Purpura, Thrombocytopenic, Idiopathic; Liver Diseases; Anemia, Aplastic; Cardiovascular Diseases; Thrombocytopenia; Lymphoma | Details |
| Recombinant human thrombopoietin | rhTPO (3SBio) | Approved | Shenyang Sunshine Pharmaceutical Co Ltd | 特比奥, Tpiao, 特比澳 | Mainland China | Thrombocytopenia; Purpura, Thrombocytopenic, Idiopathic | Shenyang Sunshine Pharmaceutical Co Ltd | 2005-03-10 | Purpura, Thrombocytopenic, Idiopathic; Leukemia; Neutropenia; Plasmacytoma; Sepsis; Liver Cirrhosis; Multiple Myeloma; Liver Diseases; Breast Neoplasms; Thrombocytopenia; Lymphoma; Leukemia, Myeloid, Acute; Myelodysplastic-Myeloproliferative Diseases | Details |