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LA3-HP2H3-50tests
$300.00
LA3-HP2H3-250tests
$1,050.00
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分子别名(Synonym)

LAG3,CD223,FDC

表达区间及表达系统(Source)

PE-Labeled Human LAG-3, His Tag (Cat. No. LA3-HP2H3) is produced via site-specific conjugation of PE to Human LAG-3, His Tag under optimal conditions with a proprietary technology. Human LAG-3, His Tag is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Leu 450 (Accession # P18627-1).

Predicted N-terminus: Leu 23

蛋白结构(Molecular Characterization)

Online-Res(Leu 23 - Leu 450) P18627-1

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 49.9 kDa.

应用说明(Application)

Flow Cytometry (Neutralizing assay)

Conjugate

PE

Excitation source: 488 nm spectral line, argon-ion laser

Excitation Wavelength: 488 nm

Emission Wavelength: 575 nm

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS with Arginine, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please protect from light and avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.

Background

Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC, which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. LAG3 /CD223 involved in lymphocyte activation. LAG3 /CD223 binds to HLA class-II antigens.