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Human WEE1 Protein, His Tag (active enzyme)

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WE1-H5543-100ug
$350.00
In Stock - Delivery in 1-2 business days
WE1-H5543-1mg
$2,310.00
In Stock - Delivery in 2-3 weeks
WE1-H5543
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  • Product Details
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Synonyms

WEE1A, WEE1hu

Source

Human WEE1 Protein, His Tag (WE1-H5543) is expressed from Baculovirus-Insect cells. It contains AA Met 215 - Tyr 646 (Accession # P30291-1).

Predicted N-terminus: Met

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 51.1 kDa. The protein migrates as 8 kDa,30-33 kDa and 55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity

>80% as determined by SDS-PAGE.

Formulation

Supplied as 0.2 μm filtered solution in 50 mM Tris, 300 mM NaCl, pH7.5 with glycerol as protectant.

Contact us for customized product form or formulation.

Shipping and Storage

This product is supplied and shipped on dry ice.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • The product MUST be stored at -70°C or lower upon receipt;
  • -70°C for 3 months under sterile conditions.
ACRO Quality Management System

Background

WEE1​​ is a ​​serine/threonine protein kinase​​ that acts as a ​​critical regulator of the cell cycle​​, particularly at the ​​G₂/M checkpoint​​. It inhibits cell cycle progression by phosphorylating and inactivating ​​CDK1​​ (Cyclin-Dependent Kinase 1) at Tyr15, thereby preventing premature entry into mitosis and allowing time for DNA repair.Originally identified in fission yeast, WEE1 is highly conserved in mammals and plays a key role in maintaining genomic stability. Dysregulation of WEE1 is linked to ​​cancer progression​​, as its overexpression in tumors (e.g., ovarian, breast, pancreatic cancers) supports cancer cell survival by enabling DNA damage tolerance. This dependency makes WEE1 a ​​promising therapeutic target​​, especially in p53-mutant cancers where inhibiting WEE1 induces synthetic lethality by forcing cells with unrepaired DNA into catastrophic mitosis.