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Human CLEC4C / BDCA2 Protein, Fc Tag

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Cat. No. / Size
Price
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CLC-H5254-100ug
$360.00
CLC-H5254-1mg
$2615.00
ETA of in-stock products:2 business days
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Product Details

  • Synonyms

    DLEC, CLEC4C, BDCA-2, CD303, CLECSF11, CLECSF7, HECL

  • Source

    Human CLEC4C, Fc Tag (CLC-H5254) is expressed from human 293 cells (HEK293). It contains AA Asn 45 - Ile 213 (Accession # Q8WTT0-1).

    Predicted N-terminus: Pro

    Request for sequence
  • Molecular Characterization

    CLEC4C Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the N-terminus.

    The protein has a calculated MW of 46.4 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    CLEC4C SDS-PAGE

    Human CLEC4C, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • Bioactivity-ELISA

     CLEC4C ELISA

    Immobilized Human CLEC4C, Fc Tag (Cat. No. CLC-H5254) at 1 μg/mL (100 μL/well) can bind Litifilimab with a linear range of 0.2-10 ng/mL (QC tested).

    Protocol

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Background

CLEC4C (C-type lectin domain family 4 member C), also known as BDCA2, CLECSF11, CLECSF7, DLEC and CD303. Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cell. Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)Glcc(beta1-2)Man. Binds to serum IgG. Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium.

Recent Advances

 
Drug Development Progress
  • English Name:

    C-Type lectin domain family 4 member C

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    9 Details

  • Highest Development Stage:

    Phase 3 Clinical

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  • Background