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Biotinylated Rabbit Anti-Eribulin Antibody, Rabbit IgG (1M1G11)

  • Antibody Internalization Detection Reagent (IGG-PZF2001) monitors endocytosis in live cells
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ERN-BMY12b-25ug
$470.00
In Stock - Delivery in 2-3 business days
ERN-BMY12b-200ug
$1845.00
In Stock - Delivery in 2 weeks
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Product Details

  • Source

    Chimeric Biotinylated Rabbit Anti-Eribulin Antibody, Rabbit IgG (1M1G11) is recombinantly expressed in HEK293. It consists of rabbit variable regions genetically fused to rabbit IgG constant domains.

  • Antibody Type

    Recombinant Monoclonal

  • Clone

    1M1G11

  • Isotype

    Rabbit IgG, Kappa

  • Host Species

    Rabbit

  • Conjugate

    Biotinylated

  • Specificity

    This product is a specific antibody specifically reacts with Eribulin.

  • Application

    Application
    Recommended Use / Performance
    ELISA
    1:200-1:2000
  • Purification

    Protein A purified.

  • Concentration

    Please refer to the Certificate of Analysis (CoA).

  • Form

    Lyophilized

  • Formulation

    Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Reconstitution

    Please refer to the Certificate of Analysis (CoA) for specific instructions.

  • Shipping

    Lyophilized product is shipped at ambient temperature.

  • Storage

    For long term storage, the product should be stored in a lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Bioactivity-ELISA

     Eribulin ELISA

    Immobilized Human FOLR1, Fc Tag (Cat. No. FO1-H5253) at 1 μg/mL, add Farletuzumab Ecteribulin and then add Biotinylated Rabbit Anti-Eribulin Antibody, Rabbit IgG (1M1G11) (Cat. No. ERN-BMY12b) at 0.05 μg/mL. Detection was performed using HRP-conjugated Streptavidin (Acro, Cat. No. STN-NH913) (QC tested).

    Protocol
  •  Eribulin ELISA

    Immobilized Human FOLR1, Fc Tag (Cat. No. FO1-H5253) at 1 μg/mL, add Farletuzumab Ecteribulin in the 100% Human Serum and then add Biotinylated Rabbit Anti-Eribulin Antibody, Rabbit IgG (1M1G11) (Cat. No. ERN-BMY12b) at 0.05 μg/mL (QC tested).

    Protocol

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Preguntas Frecuentes

  • product

    Can lyophilized proteins remain stable during room-temperature shipping or temporary room-temperature exposure?

    In general, lyophilized proteins remain stable during room-temperature shipping or temporary exposure to room-temperature conditions.


    Many ACROBiosystems recombinant proteins are supplied in lyophilized (freeze-dried) form. The lyophilization process effectively removes moisture from the product, helping reduce degradation-related reactions and improve protein stability during transportation and storage.


    To evaluate the stability of lyophilized proteins under normal temperature conditions, ACROBiosystems conducted a stability study on 11 representative lyophilized protein products at 37°C. The study demonstrated that these proteins maintained good quality stability after storage at 37°C for approximately 20 days. Based on these validation results, temporary room-temperature exposure during shipping or handling is generally not expected to have a significant impact on product quality or downstream application performance.


    To ensure optimal long-term stability, products should be stored according to the storage conditions specified in the product Certificate of Analysis (COA) upon receipt.


    Supporting Document


Background

Eribulin is a synthetic analogue of the macrocyclic polyether halichondrin B, which was originally isolated from the Asian sea sponge Halichondria okadai. Eribulin binds specifically to the β-tubulin subunit on the (+) end of the microtubule and potently inhibits elongation of the formed microtubule, while having little or no effect on microtubule depolymerization. Eribulin's potent antimitotic activity and nonmitotic effects on tumor biology make it an interesting candidate for investigation as a MTA payload for ADCs.

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  • Performance Data
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  • Preguntas Frecuentes
  • Background