Intestinal-related Solutions & Services
Intestinal organoids can be a good choice to study the differentiation process of intestinal stem cells, as well as the mechanisms of intestinal tissue regeneration and repair. In addition, they can simulate the absorption, distribution and metabolism of drugs in the Intestinal, helping evaluate the impact of drugs on the Intestinal and the therapeutic effect.
Intestinal Organoids
Intestinal organoids are miniaturized versions of the Intestinal that can be grown in the laboratory and used to study various aspects of intestinal biology and disease. The successful development of an inflammatory bowel disease (IBD) model based on intestinal organoid culture could help researchers better understand the immune response of the intestinal system in IBD and other intestinal diseases.
Drug Screening +
Drug Screening
Equipped with the ability to mimic the complex environment and physiological functions of the human Intestinal, intestinal organoids provide a more accurate prediction of drug behavior in the human body.
Intestinal Disease Modeling +
Intestinal Disease Modeling
Intestinal organoids replicate the real intestinal environment, enabling them to mimic the onset and progression of intestinal diseases more accurately.
Intestinal Adsorption Studies +
Intestinal Adsorption Studies
Intestinal organoids encompass all types of intestinal epithelial cells and possess physiological functions such as water, ion absorption, and transport. Functions such as intestinal absorption process of nutrients, as well as the transport and metabolism of drugs and bioactive substances can be evaluated.
Intestinal Development Research +
Intestinal Development Research
The developmental process of the Intestinal is mimicked through organoids, enabling observation and research on how intestinal cells grow, differentiate, and form complex tissue structures.
Intestinal organoids and differentiation kits are available to support high-throughput differentiation of intestinal organoids from iPSCs.
The culture cycle of intestinal organoids is relatively short, allowing for freezing and passage of the cultures.
The apical side is located on the outer layer, suitable for absorption tests.
The Intestinal Organoids (Cat. No. CIPO-IWL003K) differentiated using the Human iPSC-Derived Intestinal Organoid Differentiation Kit comprise multiple intestinal cell types.
| Cat. No. | Description |
| CIPO-IWL003K | Ready-to-use Human iPSC-Derived Intestinal Organoids |
| RIPO-IWM006 | Human iPSC-Derived Intestinal Organoid Maintenance Kit |
Intestinal Cells
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Intestinal Services
Organoid Differentiation and Validation Services
We offer differentiation services to develop Intestinal organoids from iPSCs or human tissue. Organoids are validated by the expression of Intestinal-related protein markers to ensure differentiation and maturity.
Validation by WB, IF, qPCR for MUC2, Villin and morphological evidence
Raw data and images
Detailed validation test report
Drug Screening
We can help measure the ability of intestinal epithelium to absorb nutrients as well as study inflammatory responses and drug-induced enterotoxicity.
Nutrition absorption test (3D)
Immune reaction test (ELISA)
Transepithelial/transendothelial electrical resistance measurement
Raw data and images
Inflammatory Bowel Disease (IBD)
We can help to construct the IBD model and provide corresponding pathological and biochemical evidence. At the same time, we can also provide you with follow-up IBD related drug screening services.
Validation by WB, IF, qPCR for pathology and immune reaction
Validation of inflammatory factors by ELISA
Detailed validation test report
Custom IBD model based on organoid
Intestinal Case Studies
Assessment of Drug Toxicity with Intestinal Organoids
Abemaciclib is a CDK4/6 inhibitor commonly used in breast cancer treatment, is frequently associated with clinical side effects such as diarrhea. Treatment of intestinal organoids with abemaciclib can simulate its effects on intestinal epithelial cells.
The integrity of the intestinal barrier depends on the function of tight junction proteins, with transepithelial electrical resistance (TEER) serving as a key indicator for evaluating barrier function—higher TEER values indicate more intact tight junctions and stronger barrier integrity.
LPS-Induced Immune Response in Intestinal Organoids
The intestinal immune system plays a vital role in maintaining gut homeostasis and protecting the host from pathogenic insults. Lipopolysaccharide (LPS), a bacterial toxin, can trigger immune responses in the intestine against pathogens.
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References
1. Li, Vivian SW. "Modelling intestinal inflammation and infection using ‘mini-gut’organoids." Nature reviews Gastroenterology & hepatology 18.2 (2021): 89-90.
2. HOFFMANN P, SCHNEPEL N, LANGEHEINE M, et al. Intestinal organoid-based 2D monolayers mimic physiological and pathophysiological properties of the pig Intestinal[J]. PLoS One, 2021, 16(8): e0256143.
- Background
- Intestinal Organoids
- Intestinal Cells
- Intestinal Services
- Intestinal Case Studies
- Related Recommendations
- References