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1. MoA：
(1) Guanylate cyclase 2C (GCC) is encoded by GUCY2C gene in human body. The receptor has an extracellular ligand binding domain, a transmembrane region, a region similar to the protein kinase sequence and a c-terminal guanylate cyclase domain. GCC signal pathway can inhibit cell proliferation, protect tight connections between cells, inhibit p53 degradation, promote DNA damage repair, reduce cell cycle progression, and promote oxidative phosphorylation.
(2) GCC is highly expressed in colorectal cancer, gastric cancer and esophageal cancer, and only in intestinal and colon tissues in normal tissues, but not in other tissues.
2. Excellent preclinical results:
(1) Compared with Benchmark (PF-07062119), this antibody has better affinity for HEK293T-hGCC cells.
(2) The binding epitope of the antibody to GCC is different from the natural ligand guanosine protein of GCC.
(3) The antibody can be rapidly internalized by 293T-hGCC cells.
(4) GCC-CD3 BsAb can effectively activate Jurkat cells; Activates T-cell-mediated cytotoxic effects.
1. Asset type: Anti-GCC humanized antibody
2. Indication: Solid Tumor (Colorectal, gastric and esophageal cancers)
3. Stage:Preclinical
4. Cooperation: sequence authorization or project transfer
5. Research progress:
(1) Ongoing Preclinical research:
Anti-GCC humanized antibody has high affinity.
It is different from the natural GCC ligand binding epitope.
GCC-CD3 BsAb can activate T cells and T-cell-mediated cytotoxic effects.
ACROBiosystems offers a wide selection of Matrigengel basement membrane extracts. Different versions – including phenol red-free, high concentration, iPSC culturing, organoid culturing – are all available for your specific needs to support 3D cell culture!
ComboX is a new brand of ACROBiosystems. ComboX products include our Streptavidin series products, coated plates, isotype controls for antibody and fusion protein drug research, and general-purpose antibodies.
To enable antibody characterization methodsACROBiosystems has developed a series of enzymes.such as ldeS, SpeB, EndoH, and Endo S proteases, toassist with the characterization of antibodies and theirrelated post-translational modifications (PTMs)
ACROBiosystems developed a series of GMP grade cytokines under the GMP grade quality management system. Those products are all suitable for T/NK cell generation, activation, and proliferation in cell therapy research.
50+ targets designed for CAR detection, including PE/FITC/biotin labeled proteins. The key reagents for CD19 and BCMA were FDA DMF filed which can support your IND, NDA and BLA process.
GMP grade cytokines, reagents for cell activation, gene edition, DNA/RNA removal, etc. Particularly focus on product design, quality control and solution-based support to link each phase of your cell and gene therapy journey.
Full length multi-pass TPs with stabilized structure and high bioactivity for immunization, antibody screening, cell based assay and CAR detection, including hot CD20, Claudin 18.2， CD133, GPRC5D，CCR8, CCR5, etc.
A series of immune checkpoints including classic co-inhibitory and co-stimulatory receptors. The comprehensive catalog contains 100+ targets with various species and tags, and the high-quality proteins are in good batch-to-batch consistency.
To meet the needs of ADCs development, ACROBiosystems can provide: A variety of high-quality target proteins; MMPs/Cathepsin/uPA for cleavable linker; Anti-payload antibodies & anti-idiotypic antibodies for immunogenicity and PK analysis; SPR/BLI analytical and ADA development service.
Comprehensive collection of Fc receptor proteins, including their common variants, which can help expedite your antibody development.
Comprehensive cytokine targets including interleukins, growth factors, chemokines, TNFs, etc. are expressed by HEK293 to ensure their natural structure. Their high purity is verified by SDS-PAGE/HPLC/SEC-MALS and high bioactivity is verified by ELISA/SPR/BLI.
Aneuro is ACROBiosystems brand focused on neuroscience research, providing high-quality important proteins including therapeutic and diagnostic research proteins, PFFs and recombinant neuro factors, etc. to advance neuroscience research.
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