1. Clear MOA
(1) The rising global prevalence of obesity, metabolic syndrome, and T2DM has driven a sharp increase in non-alcoholic steatohepatitis (NASH), which suffered over 20 million patients. There is no effective drug for NASH.
(2) Fibroblast growth factor 21 (FGF21) deficiency favors the development of steatosis, inflammation, hepatocyte damage, and fibrosis in the liver, whereas administration of FGF21 analogs ameliorates NASH by attenuating these processes.
(3) Tirzepatide is a dual GIP and GLP-1 receptor agonist approved by FDA for the treatment of T2DM and obesity. Its efficacy is better than selective GLP-1 receptor agonists.
(4) Triple targets fusion protein, combining the activity of FGF21, GLP-1 and GIP, can reduce body weight, improve glucose control and treat NASH.
2. The asset’s hypoglycemic activity is higher than Tirzepatide.
The asset significantly reduced FPG and RPG in db/db mice.
3. The asset’s weight loss and fat-reducing effect are higher than Tirzepatide.
4. The asset significantly reduces NASH scores.
It significantly reduces NASH scores (liver steatosis, ballooning of liver cells, inflammation, and liver fibrosis).
1. Asset type: GIP+GLP-1+FGF21 Fc Fusion Protein
2. Indication: NASH, T2DM, Hyperlipoidemia
3. Modality: Fusion Protein
4. Research phase: Preclinical
5. Cooperation demands: License-out or co-development the global right
6. Research progress:
(1) The asset weight loss rate is 1.6 times that of Tirzepatide.
(2) The asset significantly reduces NASH scores (liver steatosis, ballooning of liver cells, inflammation, and liver fibrosis).
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