Rat BAFFR / TNFRSF13C Protein, His Tag (HPLC verified)

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Cat. No. / Size
Price
Qty
BAR-R52H3-100ug
$395.00
BAR-R52H3-1mg (500ug X 2)
$2615.00
ETA of in-stock products:2 business days

Product Details

  • Synonym

    BAFFR, TNFRSF13C, BROMIX, CD268, CVID4, prolixin, BAFF-R

  • Source

    Rat BAFFR, His Tag (BAR-R52H3) is expressed from human 293 cells (HEK293). It contains AA Ser 10 - Asp 69 (Accession # D4A281-1).

    Request for sequence
  • Molecular Characterization

    BAFFR Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 8.7 kDa. The protein migrates as 16-30 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-HPLC.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    BAFFR SDS-PAGE

    Rat BAFFR, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-HPLC

    BAFFR SEC-HPLC

    The purity of Rat BAFFR, His Tag (Cat. No. BAR-R52H3) was greater than 95% as determined by SEC-HPLC.

  • Bioactivity-ELISA

     BAFFR ELISA

    Immobilized Mouse BAFF Protein, Mouse IgG2a Fc Tag (Cat. No. BAF-M5257) at 5 μg/mL (100 μL/well) can bind Rat BAFFR, His Tag (Cat. No. BAR-R52H3) with a linear range of 10-312 ng/mL (QC tested).

    Protocol

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Background

BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

Recent Advances

 
Drug Development Progress
  • English Name:

    B-cell activating factor receptor

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    14 Details

  • Highest Development Stage:

    NDA/BLA

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  • Background